Agents and methods for the prevention or treatment of H. pylori infections
AssigneesTechnische Universität München, Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsAnahita Javaheri, Tobias Kruse, Markus Gerhard, Bernhard B. Singer, Daniel Hornburg, Han Remaut, Matthias Mann, Felix Meissner, Steffen Backert
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Abstract
The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.
Claims4
A method of immunizing against or treating an H. pylori infection, comprising administering to a subject in need thereof a therapeutically effective amount of:
- (i) the immunogenic composition comprising:
- at least one isolated (poly-)peptide comprising the amino acid sequence of H. pylori HopQ, or an immunogenic fragment thereof, wherein the immunogenic fragment comprises an extracellular domain of H. pylori HopQ selected from the group consisting of:
- an insertion domain of H. pylori HopQ;
- loop A of H. pylori HopQ;
- loop B of H. pylori HopQ;
- loop C of H. pylori HopQ;
- loop D of H. pylori HopQ;
- and
- an immunogenic variant of the isolated (poly-)peptide having at least 90% sequence identity to one of SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 5 or SEQ ID NO:
- 15;
- or
- (ii) a composition comprising an isolated HopQ fragment comprising a HopQAD, wherein the HopQAD has an amino acid sequence corresponding to residues 37 to 463 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.