Egg allergy antigen
AssigneeHoyu Co., Ltd.
InventorsKayoko Matsunaga, Akiko Yagami, Masashi Nakamura, Yuji Aoki, Erika Kondo
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Abstract
The present invention provides a novel antigen for an egg allergy, a method for diagnosing an egg allergy and a kit for diagnosing an egg allergy, a pharmaceutical composition comprising the antigen, an egg, a processed product of an egg, or a bird which lays or has hatched from the egg in which the antigen is eliminated or reduced, a method for producing a processed product of an egg in which the antigen is eliminated or reduced, and a tester for determining the presence or absence of an egg antigen in an object of interest.
Claims7
A method for detecting binding between an egg yolk antigen and an antibody present in a sample from a human subject that specifically binds to the egg yolk antigen,
- wherein the method comprises contacting an antibody in a sample with the egg yolk antigen provided in a kit,
- wherein the egg yolk antigen is defined in (1) or (2):
- (1) (1A) a protein comprising a C-terminal portion of Vitellogenin-3, which is a protein comprising SEQ ID NO:
- 2;
- or
- (1B) a protein comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2-11;
- (2) (2A) a protein comprising a C-terminal portion of Vitellogenin-3, which is
- a protein comprising SEQ ID NO:
- 13;
- or
- (2B) a protein comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 9-11, 13, 14, and 16;
- wherein the egg yolk antigen specifically binds to IgE antibody from a patient having allergy to egg yolk,
- and
- wherein the egg yolk antigen is immobilized to a carrier or a surface.
A method for detecting binding between an egg yolk antigen and an antibody present in a sample that specifically binds to the egg yolk antigen,
- wherein the method comprises contacting an antibody in a sample with the egg yolk antigen provided in a kit,
- wherein the egg yolk antigen is:
- (1) (1A) a protein comprising a C-terminal portion of Vitellogenin-3, which is:
- a protein comprising SEQ ID NO:
- 2;
- or
- (1B) a protein comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2-11;
- (2) (2A) a protein comprising a C-terminal portion of Vitellogenin-3, which is:
- a protein comprising SEQ ID NO:
- 13;
- or
- (2B) a protein comprising at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 9-11, 13, 14, and 16;
- wherein the egg yolk antigen specifically binds to IgE antibody from a patient having allergy to egg yolk,
- and wherein the kit further comprises a reagent that detects binding between said egg yolk antigen and said antibody.
Dependencies are inferred from the claim text.