US 12,558,401 B2 · Insulinotropic and glucagonotropic effects of beta-lactoglobulin

Insulinotropic and glucagonotropic effects of beta-lactoglobulin

AssigneeArla Foods Amba

InventorsMaike Mose, Nikolaj Fibiger Rittig, Niels Møller, Ulla Ramer Mikkelsen, Pernille Dorthea Frederiksen, Kasper Bøgelund Lauridsen, Britt Christensen, Mie Markholm, Søren Bang Nielsen, Tanja Christine Jæger, Stine Bech Smedegaard, Adam Hulman

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Abstract

The present invention pertains to a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for use in preventing and/or treating a metabolic disorder and/or muscle atrophy. It also pertains to a method of preventing and/or treating a metabolic disorder and/or muscle atrophy in a subject. It furthermore pertains to use of a) beta-lactoglobulin or b) a nutritional composition comprising beta-lactoglobulin for increasing the level of insulin and/or glucagon in the blood of a subject and the present invention also pertains to a non-therapeutic use or method of a) beta-lactoglobulin orb) a nutritional composition comprising BLG. It also pertains to beta-lactoglobulin (BLG) for use in preventing and/or treating diabetes or prediabetes in a subject. It furthermore pertains to a nutritional composition for use in preventing and/or treating diabetes or prediabetes in a subject.

Claims19

Dependent claims

A method of treating muscle atrophy in a subject, the method comprising:

orally administering to a human subject in need thereof, a therapeutically effective amount of protein provided by:
a) beta-lactoglobulin;
or b) a nutritional composition comprising beta-lactoglobulin, wherein:
(i) said beta-lactoglobulin is present in an amount of at least 75% w/w relative to total protein;
and (ii) the oral administration of a) or b) to the subject increases the level of insulin in the blood of the subject when compared to a subject orally administered the same amount of protein provided by a whey protein isolate (WPI).

2 more elements

Dependencies are inferred from the claim text.