US 12,558,371 B2 · Chondroitin sulfate polysaccharide, and semi-synthetic preparation method therefor and use thereof

Abstract

The present invention relates to the technical field of medicine, in particular to a chondroitin sulfate polysaccharide, and a semi-synthetic preparation method therefor and the use thereof. A metal salt of the chondroitin sulfate polysaccharide provided by the present invention has an anti-inflammatory effect, and can be used for preparing a drug against inflammatory diseases. In particular, the metal salt of the chondroitin sulfate polysaccharide provided by the present invention has anti-inflammatory and bone-protecting effects, and can be used for preparing a drug against rheumatoid arthritis and for preparing a drug against osteoarthritis. The present invention provides a method for preparing the metal salt of the chondroitin sulfate polysaccharide, and the metal salt of the chondroitin sulfate polysaccharide with different degrees of sulfation can be obtained by semi-synthetic means in the present invention. The method is simple to operate and suitable for large-scale production.

Claims10

Dependent claims

A metal salt of chondroitin sulfate glycan having formula (I):

which is electrically neutral, and comprises a chondroitin sulfate glycan anion and a metal cation;
wherein
the chondroitin sulfate glycan anion has an average molecular weight in a range of from 4,000 Da to 15,000 Da;
the chondroitin sulfate glycan anion has a molar ratio of —SO3− to —COO− in a range of from 1.9 to 2.5;
n for the chondroitin sulfate glycan anion is within a range of 6≤n≤45;
and
in the formula (I), at least one of the R groups at 2- and 3-positions of glucuronic acid (GlcA) is SO3−.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/436,675Filed 5 Mar 2020

Priority

CN 201910163208.85 Mar 2019

Published

US 2022/0143074 A112 May 2022

Granted

24 Feb 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 31/737
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers,…:…
A61P 19/02
Drugs for skeletal disorders: for joint disorders, e.g. arthritis, arthrosis
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents
C08B 37/0069
Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan: chondroitin-4-sulfate, i.e. chondroitin…

Chondroitin sulfate polysaccharide, and semi-synthetic preparation method therefor and use thereof

Life of this patent

Chondroitin sulfate polysaccharide, and semi-synthetic preparation method therefor and use thereof

Life of this patent

Abstract

Claims10