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US 12,558,346 B2Granted
Methods and compositions for delivery of biotin to mitochondria
AssigneeSocial Profit Network
InventorHazel Szeto
Life of this patent
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Abstract
Certain exemplary embodiments are directed to a biologically active composition of matter (and uses thereof) configured for targeted delivery of biotin to mitochondria, the composition comprising a first D-biotin conjugated to a water-soluble, cell-permeable, peptide sequence, wherein the peptide sequence is selected from a polypeptide group with an alternating aromatic-cationic motif.
Claims18
A composition comprising:
- a biologically active composition of matter comprising a first D-biotin that alone is conjugated directly, via an amide bond, to an ε-amine of a C-terminal lysine residue of a water-soluble, cell-permeable, mitochondria-targeted peptide sequence to form a biotinylated polypeptide sequence,
- wherein the mitochondria-targeted peptide sequence:
- comprises a plurality of amino acids arranged with a general alternating aromatic-cationic motif;
- and
- comprises a minimum of four amino acids and a maximum of six amino acids.
2 more elements
A pharmaceutically acceptable and therapeutically effective composition comprising:
- one or more biologically active, water-soluble, cell-permeable, mitochondria-targeted compounds selected from a biotinylated polypeptide group, each biologically active, water-soluble, cell-permeable, mitochondria-targeted compound in the biotinylated polypeptide group defined by:
- a plurality of amino acids arranged with a general alternating aromatic-cationic motif;
- a minimum of four amino acids and a maximum of six amino acids;
- and
- a D-biotin that alone is conjugated directly to a ε-amine of a C-terminal lysine residue via an amide bond.
2 more elements
Dependencies are inferred from the claim text.