Oral complement factor D inhibitors

A compound of formula (Ia), or a pharmaceutically acceptable salt thereof:

• wherein:
• ring
• is arylene or heteroarylene;
• represents
• or
• ring
• is aryl or heteroaryl;
• J represents —CH2—, —NH—, —CH2CH2—, —C(O)—, —O—, —S—, —S(O)—, —SO2—, —N(alkyl)-, —CH(alkyl)-, —CH(aryl)-, —C(alkyl)2-, —CH(cycloalkyl)-, or
• K represents a bond, —O—, —NH—, —C(O)—, —CH2—, —S—, —S(O)—, —SO2—, —N(alkyl)-, —CH(alkyl)-, or —CH(cycloalkyl)-;
• wherein at least one of J and K is a bond, —C(O)—, —CH2—, —CH2CH2—, —CH(alkyl)-, or —CH(aryl)-;
• LC represents a bond, —CH2—, —CH(alkyl)-, —CH(cycloalkyl)-, —CH(hydroxyalkyl)-, —CH(haloalkyl)-, —CH2CH2—, —CF2—, —CH(F)—, —CF(alkyl)-, —C(O)—, —CD2-, or —CH(D)-;
• LD represents —CH2—, —CH2CH2—, —CF2—, —CH(F)—, —CD2-, —CH(D)-, —CH(alkyl)-, —CH(cycloalkyl)-, —CHNH2—, —CH(NH(alkyl))-, —CH(NH(cycloalkyl))-, or a bond;
• RA represents H, halo, hydroxyl, cyano, amino, alkyl, alkoxyl, hydroxyalkyl, optionally substituted aryloxy, (aryloxy)alkyl, (cycloalkyl)alkoxy, (heterocycloalkyl)alkoxy, optionally substituted (heteroaryl)alkoxy, haloalkyl, haloalkoxy, (hydroxy)haloalkyl, alkoxyalkyl, optionally substituted aminoalkyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted cycloalkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted (cycloalkyl)alkenyl, optionally substituted heterocycloalkyl, optionally substituted (heterocycloalkyl)alkyl, —C(O)OH, —C(O)NH2—, —C(O)N(alkyl)2-, —CH2C(O)OH, —NO2, —CH2NH(optionally substituted alkyl), —CH2N(Boc)(optionally substituted alkyl), —CH2NH((cycloalkyl)alkyl), —CH2N(alkyl)(cycloalkyl), —CH2N(alkyl)((cycloalkyl)alkyl), —NH(optionally substituted alkyl), —NH(cycloalkyl), —NH((cycloalkyl)alkyl), —NH((heterocycloalkyl)alkyl), —N(alkyl)2, —N(alkyl)((cycloalkyl)alkyl, —N(alkyl)((heterocycloalkyl)alkyl, —NH(heteroarylalkyl), —CH2O(optionally substituted aryl), —C(O)O(alkyl), —C(O)NH(optionally substituted alkyl), —C(O)NH((cycloalkyl)alkyl), —NHC(O)O(alkyl), or —CH2N(alkyl)2;
• RB represents H, —C(O)O(alkyl), halogen, cyano, amino, —C(O)OH, —CH2C(O)OH, —C(O)NH2, —C(O)NH(cycloalkyl), —C(O)NH(alkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)(alkyl), alkylaminoalkyl, alkylaminocycloalkyl, alkoxyalkyl, hydroxyalkyl, haloalkyl, (hydroxy)haloalkyl, or tosyl, or is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl, (cycloalkyl)alkyl, or heterocycloalkyl;
• RC represents H, halo, —OH, or amino, or is optionally substituted alkoxy, alkyl, cycloalkyl, heterocycloalkyl, or (heteroaryl)alkoxy;
• RD represents H, halo, hydroxyl, cyano, —NH2, —NH(Ac), —NH(alkyl), —N(alkyl)2, —NH(CO)(alkyl), —CH2NH2, —CH2NHC(O)(alkyl), —C(O)NH2, —C(O)OH, or —NHC(O)O(alkyl), or is optionally substituted alkyl, alkoxyl, cycloalkyl, (cycloalkyl)alkyl, hydroxyalkyl, aminoalkyl, haloalkoxyl, or haloalkyl;
• R1 represents H or optionally substituted alkyl;
• and
• m, n, p, and q are each independently 0, 1, or 2.