Insulin preparations containing methionine
AssigneeSanofi-Aventis
InventorsIsabell Schoettle, Annika Hagendorf, Christiane Fuerst, Gerrit Hauck, Verena Siefke-Henzler, Walter Kamm, Julia Schnieders
Life of this patent
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Abstract
The invention relates to an aqueous pharmaceutical formulation having insulin, an insulin analog, or an insulin derivative, and methionine; and to the production thereof, to the use thereof for treating diabetes mellitus, and to a medication for treating diabetes mellitus.
Claims5
An aqueous liquid pharmaceutical formulation comprising about 240 to 3000 nmol/ml Gly(A21), Arg(B31), Arg(B32) human insulin, about 0.089 to about 3.0 mg/ml of methionine as an antioxidative stabilizer, about 0.01 to about 0.08 mg/mL of zinc, about 1.0 to about 3.0 mg/ml of m-cresol, and about 20 mg to 30 mg/ml of glycerol, wherein the liquid pharmaceutical formulation has a pH of 2.5 to 4.5, wherein the formulation is a storable solution.
Dependencies are inferred from the claim text.