Degradable drug-loaded stent and manufacturing method therefor
AssigneeShanghai Microport Medical (Group) Co., Ltd.
InventorsWei Liu, Xueqin Wang, Yaqin Gao, Fan Qi
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Abstract
A degradable drug-loaded stent and a manufacturing method therefor. The degradable drug-loaded stent comprises a stent body, an outer surface of the stent body being provided with a drug-loaded groove, the stent body having a contracted state and an expanded state, the stent body being capable of switching from the contracted state to the expanded state via radial expansion, the stent body being a mesh columnar structure when in the expanded state, the depth of the drug-loaded groove being 10%-60% of the wall thickness of the mesh columnar structure.
Claims11
A degradable drug-loading stent, comprising a stent body, wherein the stent body is provided with a drug-loading groove at an outer surface thereof;
- the stent body has a contracted state and an expanded state, the stent body is capable of being switched from the contracted state to the expanded state by radial expansion, the stent body has a mesh columnar structure in the expanded state, and the drug-loading groove has a depth that is 10% to 60% of a wall thickness of the mesh columnar structure;
- wherein the stent body comprises a plurality of supporting unit rings and connecting rods, the supporting unit rings are connected by the connecting rods to form the mesh columnar structure, and the drug-loading groove is at least arranged on an outer surface of at least one of the supporting unit rings;
- wherein the drug-loading groove on at least one of the supporting unit rings comprises a plurality of convoluted groove sections and a plurality of connecting groove sections, the convoluted groove sections and the connecting groove sections being arranged in series to form a substantially continuous groove path;
- and
- wherein each convoluted groove section has a denser groove line than a corresponding connecting groove section, such that the convoluted groove sections provide a greater localized drug-loading capacity relative to the connecting groove sections, thereby enabling site-specific drug administration.
A method for manufacturing a degradable drug-loading stent, comprising:
- processing and shaping a tube or stent parison using a biodegradable polymer;
- processing the shaped tube or stent parison to form a stent body with a mesh columnar structure, the stent body being radially expandable and contractible;
- providing a drug-loading groove on an outer surface of the mesh columnar structure, the drug-loading groove having a depth that is 10% to 60% of a wall thickness of the mesh columnar structure;
- wherein the drug-loading groove comprises a plurality of convoluted groove sections and a plurality of connecting groove sections, the convoluted groove sections and the connecting groove sections being arranged in series to form a substantially continuous groove path;
- and wherein each convoluted groove section has a denser groove line than a corresponding connecting groove section, such that the convoluted groove sections provide a greater localized drug-loading capacity relative to the connecting groove sections, thereby enabling site-specific drug administration.
Dependencies are inferred from the claim text.