Laser interstitial thermal therapy in the operating room
AssigneeClearPoint Neuro, Inc.
InventorLyubomir Zagorchev
Life of this patent
Estimating the term…
Abstract
Examples of the presently disclosed technology provide new systems and methods for real-time temperature propagation and tissue damage visualization during laser interstitial thermal therapy (LITT) procedures that do not rely on real-time MR imaging. Accordingly, examples enable performance of LITT procedures in regular operating rooms lacking MR-equipment—thereby reducing costs and improving availability for LITT procedures. Examples achieve these advantages by leveraging “discretized” patient-specific 3D brain structure representations to perform numerical methods for solving partial differential equations that estimate real-time (or close to real-time) temperature propagation within a patient's brain during a LITT procedure.
Claims20
A non-magnetic resonance (MR)-guided method for visualizing temperature propagation during a laser interstitial thermal therapy (LITT) procedure, comprising:
- adapting a shape-constrained deformable brain model to a scan of a patient's brain to generate patient-specific 3D brain structure representations;
- discretizing the patient-specific 3D brain structure representations into volumetric elements;
- assigning tissue properties to the discretized volumetric elements based on the discretized volumetric elements' associated patient-specific 3D brain structure representations;
- defining boundary conditions for estimating a temperature propagation vector based on laser ablation-related information obtained during the LITT procedure;
- based on the defined boundary conditions and the assigned tissue properties, computing temperature propagation within the patient's brain during the LITT procedure;
- and
- displaying a visual representation of the computed temperature propagation during the LITT procedure.
A non-transitory computer-readable storage medium including instructions that, when executed by at least one processor of a computing system, cause the computing system to perform a method comprising:
- adapting a shape-constrained deformable organ model to a scan of a patient's organ to generate patient-specific 3D anatomical structure representations representing anatomical structures of the patient's organ;
- discretizing the patient-specific 3D anatomical structure representations into volumetric elements;
- assigning tissue properties to the discretized volumetric elements based on the discretized volumetric elements' associated patient-specific 3D anatomical structure representations;
- defining boundary conditions for estimating a temperature propagation vector based on laser ablation-related information obtained during a laser interstitial thermal therapy (LITT) procedure;
- based on the defined boundary conditions and the assigned tissue properties, computing temperature propagation within the patient's organ during the LITT procedure;
- and
- displaying a visual representation of the computed temperature propagation during the LITT procedure.
A system comprising:
- at least one processor;
- and
- a memory storing instructions that, when executed by the at least one processor, cause the system to perform a method comprising:
- adapting a shape-constrained deformable brain model to a scan of a patient's brain to generate patient-specific 3D brain structure representations;
- discretizing the patient-specific 3D brain structure representations into volumetric elements;
- assigning tissue properties to the discretized volumetric elements based on the discretized volumetric elements' associated patient-specific 3D brain structure representations;
- defining boundary conditions for estimating a temperature propagation vector based on laser ablation-related information obtained during a laser interstitial thermal therapy (LITT) procedure;
- based on the defined boundary conditions and the assigned tissue properties, computing temperature propagation within the patient's brain during the LITT procedure;
- based on the computed temperature propagation, estimating tissue damage within the patient's brain during the LITT procedure;
- and
- displaying a visual representation of the estimated tissue damage during the LITT procedure.
Dependencies are inferred from the claim text.