Systems and methods of on-the-fly generation of 3D dynamic images using a pre-learned spatial subspace
AssigneeCedars-Sinai Medical Center
InventorsAnthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
Life of this patent
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Abstract
A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.
Claims18
A method for performing magnetic resonance (MR) imaging on a subject, the method comprising:
- applying a first pulse sequence to a region of interest of the subject using an RF transmission system of an MR imaging apparatus;
- in response to applying the first pulse sequence to the object, obtaining initial k-space data D1 using an RF receiving system of the MR imaging apparatus;
- constructing a spatial factor Ux and a temporal factor Φ from the initial k-space data D1 using a reconstruction workstation;
- determining a transformation T that maps the initial k-space data D1 to the temporal factor Φ using the reconstruction workstation;
- generating an auxiliary temporal factor Φaux from a Bloch-simulated training dictionary, the auxiliary temporal factor Φaux containing information associated with simulated subspaces of a plurality of different image contrasts;
- projecting the temporal factor Φ onto the auxiliary temporal factor Φaux to obtain a contrast-weighted temporal factor Φcc;
- applying a second pulse sequence to the object using the RF transmission system;
- obtaining real-time k-space data D2 at time ts using the RF receiving system;
- and
- constructing, using the reconstruction workstation, a first real-time image A1ts=Ux(TD2+Δcc,ts(tc1)), the first image A1ts showing the region of interest of the subject at time ts with a first image contrast of the plurality of image contrasts present at time tc.
A method for performing magnetic resonance (MR) imaging on a subject, the method comprising:
- applying a first pulse sequence to a region of interest of the subject using an RF transmission system of an MR imaging apparatus;
- in response to applying the first pulse sequence to the object, obtaining initial k-space data D1 using an RF receiving system of the MR imaging apparatus;
- constructing a spatial factor Ux and a temporal factor Φ from the initial k-space data D1 using a reconstruction workstation;
- determining a transformation T that maps the initial k-space data D1 to the temporal factor Φ using the reconstruction workstation;
- applying a second pulse sequence to the object using the RF transmission system;
- obtaining real-time k-space data D2 at time t using the RF receiving system;
- updating the spatial factor Ux to compensate for bulk motion of the region of interest of the subject and
- constructing a real-time image A, where A=UxTD2, the real-time image A showing the region of interest of the subject at time t using the reconstruction workstation.
Dependencies are inferred from the claim text.