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US 12,553,904 B2Granted
Methods of detecting and treating cerebral aneurysms
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Upmc
InventorsRobert Max Friedlander, Michael Maurice McDowell, Aditya M. Mittal, Ali A. Alattar, Kamil W. Nowicki
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a whole blood, protein-based diagnostic test for presence and evaluation of aneurysm status. Further, the present disclosure relates to methods of treating aneurysms.
Claims18
A method for treating a cerebral aneurysm in a human subject, the method comprising:
- administering an effective amount of an aneurysm inhibitor to the subject,
- wherein the subject has an increased protein expression level of one or more biomarkers selected from the group consisting of IL-11, IL-17, and Amphiregulin relative to a reference sample of a subject without aneurysm, and
- wherein the one or more biomarkers is determined in a blood sample, a serum sample, or a plasma sample.
Dependencies are inferred from the claim text.