Method and instrument for extracting a component from a sample

A method of obtaining a liquid and an adsorbed analyte from a sample matrix, the method comprising:

• inserting a micro-syringe into the sample matrix, the micro-syringe comprising:
• a micro-syringe body comprising an orifice at an insertion end;
• and
• a plunger at least partially coated with a solid-phase micro-extraction (SPME) coating,
• wherein the plunger is shielded from the sample matrix by the micro-syringe body;
• extending the plunger so that at least a portion of the SPME coating extends past the orifice;
• allowing the SMPE coating to adsorb an analyte from the sample matrix;
• drawing the plunger into the micro-syringe body to withdraw liquid from the sample matrix into the micro-syringe body;
• and
• removing the micro-syringe from the sample matrix.

A solid-phase micro-extraction device comprising:

• a support, and
• an extraction coating covering at least a portion of the support,
• wherein the extraction coating comprises a polymeric binder and poly (divinylbenzene-co-N-vinylpyrrolidone) copolymer microparticles,
• wherein the microparticles are a polymeric reaction product of N-vinylpyrrolidone (NVP) and divinylbenzene (DVP) and the NVP and DVP reaction products are in a molar ratio from about 1:4 to about 1:2 (NVP:DVP).