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US 12,553,066 B2Granted
Gene duplications for crabtree-warburg-like aerobic xylose fermentation
AssigneeWisconsin Alumni Research Foundation
InventorsChris Todd Hittinger, Trey Sato, Sae-Byuk Lee
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Abstract
An engineered yeast strain capable of efficient fermentation of xylose to ethanol, and methods of making and using the strain, are provided.
Claims20
A recombinant yeast comprising:
- one or more recombinant nucleic acids that recombinantly express one or more of:
- a xylulokinase;
- a xylose isomerase;
- a transaldolase;
- and
- a transketolase;
- and
- one or more disabling mutations of or in one or more of:
- a Hog1 gene;
- an Isu1 gene;
- an Ira1 or Ira2 gene;
- and
- a Gre3 gene.
10 more elements
Dependencies are inferred from the claim text.