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US 12,553,028 B2Granted
Method to generate induced oligodendrocyte-lineage cells and treatment using such cells
AssigneeAcademia Sinica
InventorsJoyce Jean Lu, Hsiao-Chun Huang, Pei-Lun Lai, Chi-Hou Ng
Life of this patent
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Abstract
The present invention generally relates to a method for generating induced oligodendrocyte-lineage cells (induced OLGs) and treatment using such cells. The induced OLGs are useful in cell therapy, in particular for demyelinating diseases.
Claims16
A method of generating induced oligodendrocyte-lineage cells (induced OLGs), comprising
- culturing skin fibroblasts in a culture medium for at least one day, wherein the culture medium comprises Y27632 and SU9516 in amounts which allow 30% or more of the skin fibroblasts to reprogram into induced OLGs in one day;
- wherein induced OLGS express Oligodendrocyte Marker O4.
Dependencies are inferred from the claim text.