Antibodies to carbohydrate antigens
AssigneeRamot at Tel-Aviv University Ltd.
InventorsVered Padler-Karavani, Ron Amon, Ronit Rosenfeld
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Abstract
The present invention discloses novel monoclonal antibodies and functional fragments thereof that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity. The invention further provides compositions comprising the antibodies or fragments thereof as well as uses of the antibodies, fragments and compositions.
Claims17
A monoclonal antibody (mAb) or a fragment thereof that specifically binds to Sialyl Lewis A glycan (SLeA), wherein the mAb or the fragment comprises an antigen binding domain comprising a heavy-chain variable domain (VH) and a light-chain variable domain (VL) each comprising three complementarity determining regions (CDRs), wherein the VH-CDR 1, 2 and 3 comprise amino acid sequences SEQ ID NOs:
- 15, 12, and 8, respectively, and the VL-CDRs 1, 2 and 3 comprise amino acid sequences SEQ ID NO:
- 9, 10, and 11, respectively.
A monoclonal antibody (mAb) or a fragment thereof that specifically binds to Sialyl Lewis A glycan (SLeA), wherein the mAb or the fragment comprises an antigen binding domain comprising a heavy-chain variable domain (VH) and a light-chain variable domain (VL) each comprising three complementarity determining regions (CDRs) and four framework (FR) domains, wherein the VH-CDR 1, 2 and 3 comprise amino acid sequences SEQ ID NOs:
- 15, 12, and 8, respectively, the VL-CDRs 1, 2 and 3 comprise amino acid sequences SEQ ID NOs:
- 9, 10 and 11, respectively, the VH-FRs 1, 2 and 4 comprises acid sequences SEQ ID NOs:
- 23, 26 and 27, respectively, and the VL-FR 1 comprises acid sequence SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.