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US 12,552,848 B2Granted
Hydrochloride salts of C5a receptor agonist peptides
AssigneesBoard of Regents of the University of Nebraska, San Diego State University Research Foundation
InventorsSam D. Sanderson, Edward Leroy Morgan
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Abstract
Hydrochloride salt forms of synthetic C-terminal peptide analogs of C5a, which are response selective agonists of C5aR-bearing antigen presenting cells. Methods of inducing an immune response in a subject by administering such peptide analogs alone or in combination with other active agents are also disclosed.
Claims25
A hydrochloride (HCl) salt form of a C-terminal peptide analog of C5a, wherein the analog is a peptide comprising the formula:
- (SEQ ID NO:
- 5)
- A1-Ser-The-Lys-A2-A3-A4-A5-A6-A7
- wherein:
- A1 is Tyr, Trp, or N-acetyl derivatives of Tyr or Trp;
- A2 is Asp, Gly, Pro or N-methyl derivatives of Asp or Gly;
- A3 is Ala, Cys, Leu, Met or N-methyl derivatives of Ala, Cys, Leu or Met;
- A4 is Gln, Leu, Pro or N-methyl derivatives of Gln or Leu;
- A5 is Pro, Leu, α-methyl Leu or N-methyl Leu;
- A6 is D-Ala, Gly, D-Pro, aminoisobutyric acid (Aib) or N-methyl derivatives of D-Ala or Gly;
- and
- A7 is Arg or N-methyl Arg.
9 more elements
Dependencies are inferred from the claim text.