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US 12,552,843 B2Granted
Chimeric immunogenic polypeptides
AssigneeResearch Development Foundation
InventorsJere W. McBride, David H. Walker
Life of this patent
Estimating the term…
Abstract
Provided herein are chimeric polypeptides that may be used, e.g., for the diagnosis of or vaccination against Ehrlichia chaffeensis and/or Ehrlichia canis.
Claims35
An isolated polypeptide, wherein the isolated polypeptide comprises:
- (i) immunogenic sequences:
- TRP120 (SEQ ID NO:22), or a sequence at least 90% identical, and
- at least one of TRP32R1 (SEQ ID NO:3), TRP32R2 (SEQ ID NO:4), TRP32R3 (SEQ ID NO:5), TRP32R4 (SEQ ID NO:6), or a sequence at least 90% identical;
- and
- (ii) wherein at least one of the immunogenic sequences is contiguously repeated in the polypeptide.
2 more elements
An isolated polypeptide of Formula I (As-Bt-Cu-Dv-Ew-Fx-Gy-Hz)n,
- wherein A, B, C, D, E, F, G, and H is a peptide selected from SEQ ID NOs:1-24 and 36-42, or a sequence at least 90% identical to (SEQ ID NOs:1-24 or 36-42),
- wherein s, t, u, v, x, y, and z is an integer 0-8, wherein at least two of s-z are ≥1 and at least one of s-z is ≥2, and
- wherein n is an integer 1-5;
- wherein the polypeptide comprises TRP120 (SEQ ID NO:22), or a sequence at least 90% identical, and at least one of TRP32R1 (SEQ ID NO:3), TRP32R2 (SEQ ID NO:4), TRP32R3 (SEQ ID NO:5), TRP32R4 (SEQ ID NO:6), or a sequence at least 90% identical.
1 more element
Dependencies are inferred from the claim text.