Adeno-associated virus with engineered capsid
AssigneeTenaya Therapeutics, Inc.
InventorsZe Cheng, Christopher A. Reid
Life of this patent
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Abstract
The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein. In particular, the disclosure provides AAV9 virions with engineered AAV9 capsid, AAV5/9 chimeric capsid or combinatory capsid that achieves increased transduction efficiency in cardiac cells, increased cell-type selectivity, and/or other desirable properties.
Claims29
A recombinant adeno-associated virus (rAAV) capsid protein, comprising a variant polypeptide sequence at one or more of a VR-IV site, a VR-V site, a VR-VII site, and a VR-VIII site of a parental sequence, wherein the parental sequence comprises a sequence at least 95%, at least 98%, at least 99%, or 100% identical to SEQ ID NO:
- 463.
Dependencies are inferred from the claim text.