Compositions and methods for treating CNS disorders

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R1ia, R1lb R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• R18 is substituted or unsubstituted alkyl;
• and
• n is 0, 1, 2, or 3;
• provided that when R5 is hydrogen, R18 is not —CH3.

A compound of Formula (V):

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (VIa)

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R5a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• r is 2 or 3;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (VIb)

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• p is 2 or 3;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (VII)

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORG1, and substituted or unsubstituted alkyl, wherein RG1 is substituted or unsubstituted alkyl;
• R is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R2a, R2b, R4a, R4b, R7a, R7b, R1a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of Ra R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (VIII):

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• s is 2;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (IX):

• or a pharmaceutically acceptable salt thereof, wherein
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• and
• n is 0, 1, 2, or 3.

A compound of Formula (X):

• or a pharmaceutically acceptable salt thereof, wherein
• represents a single or double bond, provided if a double bond is present, then one of R6a or R6b is absent and R5 is absent;
• RX is selected from the group consisting of halo, —OH, —ORQ1, and substituted or unsubstituted alkyl, wherein RQ1 is substituted or unsubstituted alkyl;
• RY is halo or substituted or unsubstituted alkyl;
• or
• RY and RX may join together with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each instance of R22 is independently selected from the group consisting of halogen, —NO2, —CN, —ORGA, —N(RGA)2, —C(═O)RGA, —C(═O)ORGA, —OC(═O)RGA, —OC(═O)ORGA, —C(═O)N(RGA)2, —N(RGA)C(═O)RGA, —OC(═O)N(RGA)2, —N(RGA)C(═O)ORGA, —N(RGA)C(═O)N(RGA)2, —SRGA, —S(═O)RGA, —S(O)2RGA, —S(O)2ORGA, —OS(═O)2RGA, —S(═O)2N(RGA)2, —N(RGA)S(═O)2RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocylyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocylyl, substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclyl or heteroaryl ring;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —N(RA1)2, —SRA1, —C(═O)RA1, —C(═O)ORA1, —C(═O)SRA1, —C(═O)N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)N(RA1)2, —OC(═O)SRA1, —OS(═O)2RA1, —OS(═O)2ORA1, —OS(═O)2N(RA1)2, —N(RA1)C(═O)RA1, —N(RA1)C(═NRA1)RA1, —N(RA1)C(═O)ORA1, —N(RA1)C(═O)N(RA1)2, —N(RA1)S(═O)2RA1, —N(RA1)C(═NRA1)N(RA1)2, —N(RA1)S(═O)2ORA1, —N(RA1)S(═O)2N(RA1)2, —SC(═O)ORA1, —SC(═O)RA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —S(═O)2RA1, —S(═O)2ORA1, or —S(═O)2N(RA1)2, wherein each instance of RA1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA1 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• each of R6a and R6b is independently selected from the group consisting of hydrogen, halogen, cyano, —NO2, —OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or R6a and R6b are joined to form an oxo (═O) group;
• each of R15a, R15b, R16a, and R16b is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORC3, —N(RC3)2, —SRC3, —C(═O)RC3, —C(═O)ORC3, —C(═O)SRC3, —C(═O)N(RC3)2, —OC(═O)RC3, —OC(═O)ORC3, —OC(═O)N(RC3)2, —OC(═O)SRC3, —OS(═O)2RC3, —OS(═O)2ORC3, —OS(═O)2N(RC3)2, —N(RC3)C(═O)RC3, —N(RC3)C(═NRC3)RC3, —N(RC3)C(═O)ORC3, —N(RC3)C(═O)N(RC3)2, —N(RC3)C(═NRC3)N(RC3)2, —N(RC3)S(═O)2RC3, —N(RC3)S(═O)2ORC3, —N(RC3)S(═O)2N(RC3)2, —SC(═O)RC3, —SC(═O)ORC3, —SC(═O)SRC3, —SC(═O)N(RC3)2, —S(═O)2RC3, —S(═O)2ORC3, or —S(═O)2N(RC3)2, wherein each instance of RC3 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RC3 groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring;
• R19 is hydrogen or substituted or unsubstituted alkyl;
• q is 2;
• and
• n is 0, 1, 2, or 3.