C10-alkylene substituted 13-membered macrolides and uses thereof

A compound of Formula IIA, IIB, IIC, or IID:

• or a pharmaceutically acceptable salt thereof, wherein:
• R9a is selected from the group consisting of —H, optionally substituted C1-10 alkyl, hydroxyalkyl, optionally substituted C1-10 alkylene-NRTRT′, optionally substituted C1-10 alkylene-cycloalkyl-NRTRT′, and optionally substituted alkoxyalkyl;
• wherein RT and RT′ are each independently selected from the group consisting of —H, optionally substituted alkyl, and optionally substituted C1-10 alkylene-heterocycloalkyl;
• one of R10a and R10b is selected from the group consisting of —H and optionally substituted C1-10 alkyl;
• and
• the other of R10a and R10b is selected from the group consisting of —CO2H, —CO2— optionally substituted alkyl, optionally substituted C2-10 alkylene-R101, C2-10 alkenylene-R101, optionally substituted C2 alkylene-R101a1, optionally substituted —CH2—R101a2, —CH(OH)—R101a2, —CH(OMe)-R101a2,
• and —C(═O)—R101a2;
• R101 is selected from the group consisting of —H, —S—(C1-6 alkyl), —SO—(C1-6 alkyl), —SO2—(C1-6 alkyl), —OH, —O-alkyl, —NRxRx′, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R101a1 is selected from the group consisting of —H, —S—(C1-6 alkyl), —SO—(C1-6 alkyl), —SO2—(C1-6 alkyl), —OH, —O-alkyl, —NRxRx′, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R101a2 is selected from the group consisting of —H, —OH, —O-alkyl, —NRxRx′, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• wherein if either R10a or R10b are —H, then R101a2 is not —H;
• wherein if R10b is —H, then R101a1 is not —H;
• Rx and Rx′ are each independently selected from the group consisting of —H, optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylene-cycloalkyl, optionally substituted alkylene-heterocycloalkyl, optionally substituted alkylene-aryl, optionally substituted alkylene-heteroaryl, —C(═O)-alkyl, and —C(═O)-alkylene-N(Ry′) (Ry″);
• wherein Ry′ and Ry″ are each independently —H or optionally substituted alkyl;
• or
• Rx and Rx′ together with the atom to which they are attached form an optionally substituted 3-, 4-, 5-, 6-, or 7-membered ring optionally containing an additional heteroatom selected from the group consisting of O, S, SO, SO2, NRy, and N—(C1-10 alkyl);
• and wherein:
• each Ry is independently selected from the group consisting of —H and optionally substituted C1-10 alkyl.