C-mannoside compounds useful for the treatment of urinary tract infections
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsMichael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
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Abstract
Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
Claims14
A method of prevention of a FimH-mediated disease in a human in need thereof, comprising administering to the human a pharmaceutical composition comprising a therapeutically effective amount of a compound which is:
- or pharmaceutically acceptable salt thereof,
- wherein said disease is a bacterial infection and said bacterial infection is a urinary tract infection and wherein said urinary tract infection is recurrent or chronic.
A method of inhibiting FimH activity in a human subject in need thereof comprising administering to the human subject a pharmaceutical composition comprising a therapeutically effective amount of a compound which is
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.