Pyridone multiple-membered ring derivatives and use thereof

A compound of formula (VI) or a pharmaceutically acceptable salt thereof,

• wherein
• R7 is selected from H and
• R8 is selected from C1-3 alkyl and
• and the C1-3 alkyl and
• are optionally substituted by 1, 2, or 3 Ra;
• R9 is selected from H, E1 is selected from Se, X1 is selected from CR10R11, and R10 and R11 together with the atom to which they are commonly connected form a C3-5 cycloalkyl group;
• alternatively, X1 and R9 together with the atom to which they are connected form
• p is selected from 0 and 1, one of E1 and E2 is selected from Se, and the other is selected from S and O;
• each R12 is independently selected from H, F, Cl, Br, I, OH, NH2, —COOH, C1-3 alkyl, C1-3 alkoxy, and C1-3 alkylamino, and the C1-3 alkyl, C1-3 alkoxy, and C1-3 alkylamino are independently substituted by 1, 2, or 3 Rb;
• T1, T2, T3, and T4 are each independently selected from CH and N;
• q is selected from 0 and 1;
• t is selected from 0, 1, 2, 3, and 4;
• each Ra and Rb is independently selected from H, F, Cl, Br, and I;
• provided that when T1 is selected from CH, E1 is selected from Se, E2 is selected from O, p is selected from 1, and q is selected from 1, each R12 is independently selected from OH and NH2.