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US 12,552,756 B2Granted
Deuterated aminothiazole compounds as antiviral compounds
AssigneeInnovative Molecules GmbH
InventorsChristian Gege, Gerald Kleymann
Life of this patent
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Abstract
The invention relates to novel deuterated compounds of Formula (I) to a process for their preparation and to their use as medicament, in particular as antiviral medicament.
Claims23
A compound of Formula (I):
- or an enantiomer, diastereomer, tautomer, solvate, or pharmaceutically acceptable salt thereof, wherein
- X is selected from
- or X is a group
- R1 is selected from C1-4-alkyl and fluoro-C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R2 is selected from H, —CN, fluoro-C1-4-alkyl and C1-4-acyl, said C1-4-alkyl or C1-4-acyl having one or more hydrogen atoms optionally replaced by deuterium;
- R3 is selected from H and C1-4-alkyl and fluoro-C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R4 is selected from H and C1-6-alkyl, said C1-6-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R5 and R6 are independently selected from H, D (deuterium) and C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R8 is selected from H, —CN, —NO2, C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R9 is selected from C1-4-alkyl, fluoro-C1-4-alkyl, C3-4-cycloalkyl and fluoro-C3-4-cycloalkyl, said C1-4-alkyl or C3-4-cycloalkyl having one or more hydrogen atoms optionally replaced by deuterium;
- Y is a group
- wherein
- R11, R12, R13 and R14 are independently selected from H, D, halogen, CN, C1-4-alkyl and fluoro-C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- R21, R22, R23, R24 and R25 are independently selected from H, D, halogen, CN, C1-4-alkyl, O—C1-4-alkyl, fluoro-C1-4-alkyl and O-fluoro-C1-4-alkyl, said C1-4-alkyl having one or more hydrogen atoms optionally replaced by deuterium;
- provided that at least one hydrogen in R1, R2, R3, R4, R5, R6, R8, R9, R11, R12, R13, R14, R21, R22, R23, R24 or R25 is replaced by deuterium.
12 more elements
Dependencies are inferred from the claim text.