Back to results
US 12,552,755 B2Granted
Cinnamic amide derivative having FXR activating effect, pharmaceutical composition containing the same as active ingredient, and method for preparing the same
AssigneesKyungsung University Industry Cooperation Foundation, Pusan National University Industry-University Cooperation Foundation
InventorsJae-Hwan Kwak, Young-Suk Jung, Doyoung Kwon, Min Woo Kim, Sou Hyun Kim
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to a pharmaceutical composition containing a cinnamic amide derivative that activates FXR or an isomer, solvate, or pharmaceutically acceptable salt thereof, and a method for preparing the same.
Claims7
A cinnamic amide derivative selected from the following Table 5, a solvate, or a pharmaceutically acceptable salt of the cinnamic amide derivative:
- TABLE 5
- No.
- Name
- KS-
- Ethyl (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 010
- yl)methoxy)phenyl)acryloyl)glycinate
- KS-
- ethyl (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 025
- yl)methoxy)phenyl)acryloyl)-L-alaninate
- KS-
- (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 028
- yl)methoxy)phenyl)acryloyl)-L-alanine
- KS-
- (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 034
- yl)methoxy)phenyl)acryloyl)-L-valine
- KS-
- methyl (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-
- 037
- 4-yl)methoxy)phenyl)acryloyl)-L-phenylalaninate
- KS-
- (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 040
- yl)methoxy)phenyl)acryloyl)-L-phenylalanine
- KS-
- methyl (E)-3-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-
- 043
- 4-yl)methoxy)phenyl)acrylamido)propanoate
- KS-
- (E)-3-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 046
- yl)methoxy)phenyl)acrylamido)propanoic acid
- KS-
- methyl (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-
- 049
- 4-yl)methoxy)phenyl)acryloyl)-D-alaninate
- KS-
- (E)-(3-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-
- 052
- yl)methoxy)phenyl)acryloyl)-D-alanine.
40 more elements
Dependencies are inferred from the claim text.