Salts of (2R, 6R)-hydroxynorketamine, their crystal forms, and methods of making the same
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, The Unviersity of Maryland, Baltimore, The United States Government as represented by the Department of Veterans Affairs
InventorsPatrick Joseph Morris, Craig Joseph Thomas, Stephen J. Byard, Martin P. Wilmshurst, Todd Gould, Carlos Zarate, Ruin Moaddel
Life of this patent
Estimating the term…
Abstract
The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.
Claims14
A crystalline addition salt of (2R,6R)-hydroxynorketamine and an organic acid, wherein the organic acid is malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid,
- wherein the crystalline addition salt of (2R,6R)-hydroxynorketamine and malonic acid exhibit a XRPD spectrum having peaks at the following values:
- 9.4, 12.6, and 15.2 degrees 2θ+/−0.2 degrees 2θ;
- and
- wherein the crystalline addition salt of (2R,6R)-hydroxynorketamine and salicylic acid exhibits a XRPD spectrum having peaks at the following values:
- 9.8, 10.2, and 25.5 degrees 2θ+/−0.2 degrees 2θ.
Dependencies are inferred from the claim text.