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US 12,552,736 B2Granted
Compositions for preventing and/or treating degenerative disorders of the central nervous system and/or lysosomal storage disorders
AssigneeAmicus Therapeutics, Inc.
InventorRobert Boyd
Life of this patent
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Abstract
The present invention provides methods for treating lysosomal storage disorders such as Gaucher's disease, by using compounds of Formula III as described herein.
Claims16
A method for treating a Gaucher's disease, which comprises administering to the patient in need thereof an effective amount of a compound of Formula III:
- wherein:
- R1 is C(R2)(R3)(R4);
- R2 is selected from the group consisting of hydrogen, —OH or halogen;
- R3 is selected from the group consisting of hydrogen, —OH, halogen or —CH3;
- R4 is selected from the group consisting of hydrogen, halogen, —CH3, phenyl, fluorophenyl, methylphenyl or cyclohexylmethyl;
- R3 and R4 may join with the carbon to which they are attached to form a cycloalkyl ring, which may be optionally substituted with one or more halogen atoms;
- R6 is selected from the group consisting of —OH or halogen;
- R8 is selected from the group consisting of —OH or halogen;
- and
- R10 is selected from the group consisting of —OH or halogen, provided that that at least one of R2, R3, R4, R6, R8 or R10 comprises a halogen.
7 more elements
A method for treating Gaucher's disease, which comprises administering to the patient in need thereof an effective amount of a compound selected from the group consisting of the following:
- or a pharmaceutically acceptable salt, or solvate, or prodrug thereof.
Dependencies are inferred from the claim text.