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US 12,552,733 B2Granted
Terpenophenolic compounds and their use
AssigneePhytotherapeutix Limited
InventorColin George Stott
Life of this patent
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Abstract
The present disclosure describes terpenophenolic compounds and their use in medicine. The present disclosure further describes perrottetinene-like compounds, the manufacture thereof, formulations containing same and their use in medicine. Such compounds include (1′R, 2′R)-5′-methyl-phenethyl-2′-(prop-1-ene-2-yl)-1′, 2′, 3, 4′-tetrahydro-[1, 1-biphenyl]-2,6-diol (CBD-PET) or (1′R,2′R)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′, 2′, 3, 4′-tetrahydro-[1, 1′-biphenyl]-2,6-diol (CBD-PET-OH).
Claims22
A compound, which is any one selected from the group consisting of:
- (a) 4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-diol (CBD-PET-OH)
- and
- (b) (1′R,2′R)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-diol ((−) trans-CBD-PET-OH)
- and
- (c) compound (1'S,2'S)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-diol ((+) cis CBD-PET-OH)
- and
- (d) (1′R,2'S)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′,2′,3′,4′-tetrahyrdo-[1,1′-biphenyl]-2,6-diol((−) cis- CBD-PET-OH)
- (e) (1'S,2′R)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-diol ((+) cis CBD-PET-OH)
- and
- (f) an o-isomer of trans-CBD-PET-OH having a structure:
- or a pharmaceutically acceptable salt or hydrate of one of (a) through (f) thereof.
8 more elements
Dependencies are inferred from the claim text.