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US 12,551,895 B2Granted
Multi-cartridge digital microfluidics apparatuses and methods of use
AssigneeIntegra Biosciences AG
InventorsJorge Abraham Soto-Moreno, Mais Jehan Jebrail, Juan Matias DeCarli
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Abstract
High-throughput digital microfluidic (DMF) systems and methods (including devices, systems, cartridges, DMF apparatuses, etc.), are described herein. The systems, apparatuses and methods integrate liquid handling with the DMF apparatuses, providing flexible and efficient sample reactions and sample preparation. These systems, apparatuses and methods may be used with a variety of cartridge configurations and sizes.
Claims11
A method of selectively immobilizing one or more cartridges in a digital microfluidics apparatus having a plurality of driving electrodes, the method comprising:
- disposing one or more cartridges on a seating surface of the digital microfluidics apparatus, thereby defining one or more respective seating locations of the one or more cartridges, wherein each of the one or more cartridge sits on a sub-region of the seating surface;
- sensing each respective seating locations of the one or more cartridges;
- determining a sub-set of the plurality of driving electrodes underlying the respective seating locations of the one or more cartridges;
- and
- selectively applying a vacuum to the respective seating locations of the one or more cartridges to immobilize the one or more cartridges to the seating surface of the digital microfluidics apparatus.
2 more elements
Dependencies are inferred from the claim text.