Modification of surface properties of microfluidic devices
AssigneeBio-Rad Laboratories, Inc.
InventorsJoshua Ritchey, Yi Xue, Robert Meltzer
Life of this patent
Estimating the term…
Abstract
Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.
Claims9
A device comprising a microfluidic channel having an inner coated polymer surface comprising:
- a substrate layer comprising a hydrophobic polymer;
- and
- a coating layer comprising a silicone polymer and hydrophobic silica, wherein the coating layer is adsorbed to at least a portion of the substrate layer.
Dependencies are inferred from the claim text.