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US 12,551,865 B2Granted
Silica-based particle with hydroxy-terminated PEG bonding and methoxy-terminated PEG surface modification
AssigneeWaters Technologies Corporation
InventorsNicole L. Lawrence, Yeliz Tunc Sarisozen, Darryl W. Brousmiche, Matthew A. Lauber
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to stationary phase materials for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylene glycol surface modified silica particle stationary phase materials, which are optionally also methoxy-terminated polyethylene glycol surface modified.
Claims18
A stationary phase material comprising porous silica particles having a surface, the surface comprising:
- (a) hydroxy-terminated polyethylene glycol ligands, wherein the hydroxy-terminated polyethylene glycol ligands are present on the surface at a density from about 0.5 to about 15 μmol/m2;
- and
- (b) methoxy-terminated polyethylene glycol ligands.
Dependencies are inferred from the claim text.