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US 12,551,864 B2Granted
Double surface modified porous material with minimized nonspecific interaction
AssigneeWaters Technologies Corporation
InventorsYeliz Tunc Sarisozen, Nicole L. Lawrence, Darryl W. Brousmiche, MingCheng Xu, Kevin Wyndham
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Abstract
The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.
Claims18
A material having a surface, wherein said surface is modified with:
- a moiety comprising a polyethylene glycol (PEG) functionality at a coverage density of from about 0.05 μmol/m2 to about 15 μmol/m2;
- and
- a moiety comprising a diol functionality at a coverage density of at least 0.05 μmol/m2,
- wherein the moiety comprising the diol functionality comprises an alkylsilane having a diol terminus.
1 more element
Dependencies are inferred from the claim text.