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US 12,551,852 B2Granted
Secondary statistical cutoff methodology for gas-liquid diffusion integrity testing
AssigneeEMD Millipore Corporation
InventorsRebecca Rodenhiser, Salvatore Giglia, Christopher Johnson
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Abstract
The disclosure herein relates to a method of reducing background noise during integrity testing of membrane filter to increase sensitivity and more effectively disposition failing membrane filters.
Claims24
A method of reducing background noise and improving the signal to noise ratio in integrity testing to disposition a membrane filter comprising:
- performing a gas-liquid diffusion analysis on the membrane filter, the method;
- identifying whether the membrane filter is an outlier compared to an initial fixed cutoff during the gas-liquid diffusion analysis;
- if the membrane filter is not an outlier compared to the initial fixed cutoff, then normalizing a value of at least one property of the membrane filter that impacts a background noise in the gas-liquid diffusion analysis;
- and
- identifying whether the membrane filter is an outlier compared to a secondary statistical cutoff based on values of at least two properties of a plurality of membrane filters from gas-liquid diffusion analyses of the plurality of membrane filters;
- and
- dispositioning the membrane filter as integral or failing.
4 more elements
Dependencies are inferred from the claim text.