Multi-beam neuromodulation techniques

A method comprising:

• receiving image data of a tissue of a subject;
• dividing the image data of the tissue into a plurality of segments;
• selecting a plurality of regions of interest in the tissue associated with respective segments of the plurality of segments;
• controlling an ultrasound transducer to apply an ultrasound energy dose distributed between the plurality of regions of interest, wherein the ultrasound energy dose is distributed between at least two separate and distinct ultrasound beams, wherein a first beam targets a first organ and a second beam targets a second organ that is different from the first organ, wherein the first organ and the second organ each receive a respective fraction of a total ultrasound energy dose, wherein energy applied to the first organ is limited below a first threshold and energy applied to the second organ is limited below a second threshold, wherein a cumulative applied ultrasound energy dose to the plurality of regions of interest is equal to the total ultrasound energy dose, and wherein the first organ and the second organ comprise at least one axon terminal of a neuron, the axon terminal forming a synapse with a non-neuronal cell;
• assessing an effectiveness of the ultrasound energy dose;
• and
• modifying instructions to apply a subsequent ultrasound energy dose of a neuromodulation treatment based on the assessing, wherein modifying the instructions comprises changing a relative distribution of ultrasound energy between the plurality of regions of interest of the subsequent ultrasound energy dose such that the relative distribution is changed to increase a fraction of the subsequent ultrasound energy dose applied to an individual region of interest in the first organ based on a change in concentration of one or more molecules of interest, and wherein a corresponding fraction of the total ultrasound energy dose applied to a different region of interest in the second organ is correspondingly decreased.

A system, comprising:

• an ultrasound energy application device;
• and
• a controller configured to:
• distribute an ultrasound energy dose between a plurality of regions of interest, wherein the ultrasound energy dose is distributed between at least two separate and distinct ultrasound beams, wherein a first beam targets a first organ and a second beam targets a second organ that is different than the first organ, wherein the first organ and the second organ each receive a respective fraction of a total ultrasound energy dose, wherein energy applied to the first organ is limited below a first threshold and energy applied to the second organ is limited below a second threshold, and wherein a cumulative applied ultrasound energy to the plurality of regions of interest is equal to the total ultrasound energy dose;
• assess an effectiveness of the ultrasound energy dose;
• and
• modify instructions to apply a subsequent ultrasound energy dose of a neuromodulation treatment based on the assessing, wherein modifying the instructions comprises changing a relative distribution of ultrasound energy between the plurality of regions of interest of the subsequent ultrasound energy dose such that the relative distribution is changed to increase a fraction of the subsequent ultrasound energy dose applied to an individual region of interest in the first organ based on a change in concentration of one or more molecules of interest, and wherein a corresponding fraction of the total ultrasound energy dose applied to a different region of interest in the second organ is correspondingly decreased.