Radiolabeled ligands for targeted PET/SPECT imaging and methods of their use
AssigneesMemorial Sloan Kettering Cancer Center, University of Rhode Island Board of Trustees, Phlip, Inc.
InventorsJason S. Lewis, Dustin Demoin, Yana K. Reshetnyak, Oleg A. Andreev, Nerissa Viola-Villegas
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Abstract
The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
Claims12
A compound or pharmaceutically acceptable salt thereof comprising a pH (low) insertion peptide (“pHLIP”), wherein
- X1 is covalently attached to a sulfur atom of a side chain of an amino acid residue of the pHLIP;
- wherein
- X1 is of Formula Ia
- where
- Z1 and Z2 are each independently a lone pair of electrons or H;
- and the compound is ADDQNPWRAYLDLLFPTDTLLLDLLWC(X1)G (SEQ ID NO:7) or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.