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US 12,551,533 B2Granted
Intranasal neuropeptides for use in stress-related impairments
AssigneeNew York Medical College
InventorEsther L. Sabban
Life of this patent
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Abstract
Intranasal neuropeptide Y (NPY) analogs having D-amino acids, such as [D26-His]-NPY are provided for early intervention to prevent or to treat, to reverse, or reduce symptoms of stress-related impairments such as PTSD, depression, substance abuse, and/or memory deficits following exposure to traumatic or surgical stress.
Claims14
A method for treating a subject suffering from or diagnosed with a stress related impairment selected from the group consisting of (i) depression;
- and (ii) post-traumatic stress disorder (PTSD) with one or more PTSD associated symptoms including anxiety, depression and impaired social interactions, said method comprising intranasal administration to the subject in need thereof of a therapeutically effective amount of a neuropeptide Y (NPY) analog wherein said NPY analog is [D-His26]-NPY.
A prophylactic method for preventing a stress related impairment selected from the group consisting of (i) depression;
- and (ii) post-traumatic stress disorder (PTSD) with one or more PTSD associated symptoms including anxiety, depression and impaired social interactions, said method comprising intranasal administration to the subject in need thereof of a therapeutically effective amount of a neuropeptide Y (NPY) analog wherein said NPY analog is [D-His26]-NPY and wherein the subject in need thereof has been, or will be, subjected to traumatic stress.
Dependencies are inferred from the claim text.