Compounds and methods for treating or reducing pruritus
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMartha Bhattacharya, Tally Largent-Milnes
Life of this patent
Estimating the term…
Abstract
The present invention features methods and compositions for preventing, inhibiting, or reducing the sensation of itch (pruritus) by modulating the gene expression of TMEM184B. Modulating the gene expression of TMEM184B may comprise increasing Tmem184B protein expression, increasing Tmem184B protein activity or both. Furthermore, the methods and compositions described herein may activate the Tmem184B protein or activate a pathway leading to Tmem184B activation. Additionally, the methods and compositions for modulating the gene expression of TMEM184B may be used to help prevent or treat certain diseases or conditions such as dermatitis.
Claims8
A method of treating sensation of itch or pruritus in a subject in need thereof, said method comprising administering a compound comprising a recombinant TMEM184B or a nucleic acid vector encoding thereof to the subject to cause a reduction in the sensation of itch or pruritus.
A method of treating dermatitis in a subject in need thereof, said method comprising administering a compound comprising a recombinant TMEM184B or a nucleic acid vector encoding thereof to the subject to cause a reduction in dermatitis.
Dependencies are inferred from the claim text.