N4-hydroxycytidine and derivatives and anti-viral uses related thereto

A compound having the formula:

• or salt thereof, wherein
• Q is O;
• W is O;
• X is CH2;
• Y is CR″;
• Z is CR″;
• each R″ is H;
• R1 is
• carboxy, carbonyl, esteryl, or formyl, or R1O— is carboxylic acid ester, wherein R1 is optionally substituted with one or more, the same or different, R20;
• R2 is hydrogen:
• R3 and R4 are alkoxy, optionally substituted with one or more, the same or different, R20;
• R5 is hydrogen;
• R6 is hydrogen;
• R7 is hydrogen or (C1-C22)alkyl, wherein R7 is optionally substituted with one or more, the same or different, R20;
• R8 is hydrogen;
• R9 is (C1-C22)alkyl;
• Y1 is O;
• Y2 is OR12;
• R12 is (C1-C22)alkyl, wherein R12 is optionally substituted with one or more, the same or different, R20;
• R20 is alkyl, alkoxy, cyano, carboxy, carbocyclyl, (C1-C22)alkylamino, aryl, or heterocyclyl, wherein R20 is optionally substituted with one or more, the same or different, R21;
• and
• R21 is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl.