Enthesis healing
AssigneeUniversity of Utah Research Foundation
InventorsRobert Z. Tashjian, Peter N. Chalmers, T. Wade Fallin, James M. Hotaling
Life of this patent
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Abstract
Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.
Claims29
A method of improving healing of an enthesis of a subject in need thereof, the method comprising:
- locally administering to the subject, at a target enthesis site, an effective amount of a composition comprising
- (i) an estrogen, wherein the estrogen comprises one or more of estrone, estradiol, estriol, or ester or ether thereof,
- (ii) an androgen and/or androgen equivalent, wherein the androgen comprises one or more of testosterone, dihydrotestosterone, androstenedione, or ester or ether thereof, and wherein the androgen equivalent comprises a selective androgen receptor modulator, or
- (iii) combination thereof,
- to thereby increase levels of at least one sex steroid at the target enthesis site,
- wherein the composition is included in a drug-eluting implant,
- wherein the drug-eluting implant is placed in a formed cavity in bone tissue at the target enthesis site;
- and
- the composition improving healing of an enthesis in the subject.
A method of improving healing of an enthesis of a subject in need thereof, the method comprising:
- locally administering to the subject, at a target enthesis site, an effective amount of a composition comprising
- (i) an estrogen, wherein the estrogen comprises estrone, estradiol, estriol, ester thereof, ether thereof, or combination thereof,
- (ii) an androgen and/or androgen equivalent, wherein the androgen comprises testosterone, dihydrotestosterone, androstenedione, ester thereof, ether thereof, or combination thereof, and wherein the androgen equivalent comprises a selective androgen receptor modulator, or
- (iii) combination thereof,
- wherein the composition omits selective estrogen receptor modulators,
- to thereby increase levels of at least one sex steroid at the target enthesis site,
- wherein the composition is included in a drug-eluting implant,
- wherein the drug-eluting implant is placed adjacent to or internal to a ligament or a tendon at the target enthesis site;
- and
- the composition improving healing of an enthesis in the subject.
A method of improving healing of an enthesis of a subject in need thereof, the method comprising:
- locally administering to the subject, at a target enthesis site, an effective amount of a composition comprising
- (i) an estrogen, wherein the estrogen comprises estrone, estradiol, estriol, ester thereof, ether thereof, or combination thereof,
- (ii) an androgen and/or androgen equivalent, wherein the androgen comprises testosterone, dihydrotestosterone, androstenedione, ester thereof, ether thereof, or combination thereof, and wherein the androgen equivalent comprises a selective androgen receptor modulator, or
- (iii) combination thereof,
- wherein the composition omits selective estrogen receptor modulators,
- to thereby increase levels of at least one sex steroid at the target enthesis site.
Dependencies are inferred from the claim text.