Oral antagonist compositions for nicotine burning relief

An oral buffered nicotine product comprising:

• one or more nicotine sources selected from the group consisting of nicotine bitartrate, nicotine polacrilex resin, free base nicotine, and combinations thereof, constituting a total nicotine content of 0.5 to 20.0 mg in the oral buffered nicotine product;
• one or more buffering agents present in an amount of 1.0% to 5.0% by weight of the oral buffered nicotine product selected from the group consisting of potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, potassium citrate, dipotassium phosphate, and combinations thereof;
• and
• an analgesic composition for alleviation of perceived nicotine irritation through inhibition or blocking of nicotine activated receptors or ion channels in the gastrointestinal tract, including the oral cavity, the composition comprising:
• at least two antagonists in an effective amount to inhibit or block nicotine agonist activation of Nicotinic Acetylcholine Receptors (nAChR) and/or Transient Receptor Potential (TRP) ion channels, the at least two antagonists being selected from the group consisting of:
• a first antagonist comprising camphor,
• a second antagonist comprising eucalyptol, and
• a third antagonist comprising (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide (WS-12),
• wherein the at least two antagonists and nicotine are present in a weight ratio of 1:2 to 2:1, and wherein the at least two antagonists are present in a total amount effective to reduce perceived nicotine irritation by more than 20% compared to presence of only one of the same at least two antagonists in the same total amount, and wherein the unit weight of the oral buffered nicotine product is from 50 to 2000 mg.