Supraparticle formulations
AssigneesThe Bionics Institute of Australia, The University of Melbourne
InventorsAndrew Wise, Yutian Ma, Frank Caruso, Mattias Björnmalm
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Abstract
The present disclosure relates to supraparticles loaded with high levels of payload and having controlled payload release profiles. In particular, supraparticles made of mesoporous silica nanoparticles and elecrosprayed with alginic acid which is then coated or formulated with biodegradable materials is disclosed. Such supraparticles may be used in a range of therapeutic applications.
Claims20
A composition comprising a mesoporous-silica supraparticle (MS-SP), wherein the MS-SP comprises:
- at least 1.5 μg of a neurotrophic factor payload;
- and
- a biodegradable coating;
- wherein the biodegradable coating is applied as one, two, or three layers on the MS-SP pre-loaded with the neurotrophic factor payload;
- and
- wherein the biodegradable coating reduces the initial burst release of the neurotrophic factor payload from the supraparticle to less than about 30% at three days in phosphate buffered saline (PBS) at 37° C., compared to a MS-SP without the biodegradable coating.
A composition comprising a mesoporous-silica supraparticle (MS-SP), wherein the MS-SP comprises:
- at least 1.5 ug of a neurotrophic factor payload;
- and
- a biodegradable coating;
- wherein the biodegradable coating is applied as one, two, or three layers on the MS-SP pre-loaded with the neurotrophic factor payload;
- and
- wherein the MS-SP with the biodegradable coating is characterized by around 3-25% neurotrophic factor payload release over the first 7 days in phosphate buffered saline (PBS) at 37° C.
Dependencies are inferred from the claim text.