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US 12,551,442 B2Granted
Multifunctional microsphere preparation for chemoembolization therapy and imaging of tumors, and preparation method therefor
AssigneeFudan University
InventorsYuyi Qian, Wei Lu
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Abstract
In the microsphere preparation for chemoembolization therapy and nuclear medicine imaging of tumor, and a preparation method thereof, the microsphere is formed by means of using a polyvinyl alcohol derivative as a framework material and polymerizing, crosslinking and curing same with an N-acryl amino acid monomer. The microsphere can label radionuclide iodine and can also absorb load chemotherapeutic drugs.
Claims11
A microsphere prepared by polymerization and crosslinking of N-acryl amino acid monomers of general structure (1) and polyvinyl alcohol derivative macromolecular monomers of simple structure (2)
- where R is one or more of the following structures:
- characterized in that the molecular weight range is 10 kDa˜1000 kDa, formed by the aldolization of N-(2, 2-dimethoxyethyl)-2-acrylamide with the hydroxyl group of polyvinyl alcohol, wherein the substitution degree range of N-(2, 2-dimethoxyethyl)-2-acrylamide is 0.1%˜40%;
- and the molar ratio of the aforementioned N-acryl amino acid monomer and the polyvinyl alcohol derivative macromolecular monomer ranges from 50:1 to 1000:1 and the
- aforementioned microsphere preparation is able to be labeled with radionuclide iodine and simultaneously load chemotherapy agents.
1 more element
Dependencies are inferred from the claim text.