Flowpack for oral delivery of active ingredients
AssigneeFertin Pharma A/S
InventorsHelle Wittorff, Christine Nøhr Pedersen
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Abstract
A flowpack for oral delivery of active ingredients comprises a population of particles and one or more active ingredients, the population of particles including at least two types of sugar alcohol particles, wherein at least one of said two types of sugar alcohol particles comprises granulated sugar alcohol particles.
Claims28
A flowpack for oral delivery of active ingredients, the flowpack comprising an outer package material enclosing a dissolvable unstamped powder delivery system as the entire content of matter filled into the flowpack comprising:
- a population of particles;
- and
- one or more active ingredients,
- the population of particles including at least two types of sugar alcohol particles with different particle size distributions that are all flowable, wherein at least one of said at least two types of sugar alcohol particles comprises granulated sugar alcohol particles in an amount of at least 20% by weight of the dissolvable unstamped powder delivery system and at least one of said at least two types of sugar alcohol particles, apart from said granulated sugar alcohol particles, have a particle size with more than 80% of the particles being below 500 microns, and wherein a Hausner ratio of the dissolvable unstamped powder delivery system is between 1.00 and 1.45.
A flowpack for oral delivery of active ingredients, the flowpack comprising an outer package material enclosing a dissolvable unstamped powder delivery system as the entire content of matter filled into the flowpack comprising:
- a population of particles;
- and
- one or more active ingredients,
- the population of particles including at least two types of sugar alcohol particles with different particle size distributions that are all flowable, wherein at least one of said at least two types of sugar alcohol particles comprises granulated sugar alcohol particles in an amount of at least 20% by weight of the dissolvable unstamped powder delivery system and at least one of said at least two types of sugar alcohol particles, apart from said granulated sugar alcohol particles, comprises non-directly compressible (non-DC) sugar alcohol particles having a particle size with more than 80% of the particles being below 500 microns, and wherein a Hausner ratio of the dissolvable unstamped powder delivery system is between 1.00 and 1.45.
A flowpack for oral delivery of active ingredients, the flowpack comprising an outer package material enclosing a dissolvable unstamped powder delivery system as the entire content of matter filled into the flowpack comprising:
- a population of particles;
- and
- one or more active ingredients,
- the population of particles including at least two types of sugar alcohol particles with different particle size distributions that are all flowable, wherein at least one of said at least two types of sugar alcohol particles comprises granulated sugar alcohol particles in an amount of at least 20% by weight of the dissolvable unstamped powder delivery system and at least one of said at least two types of sugar alcohol particles, apart from said granulated sugar alcohol particles, comprises directly compressible (DC) sugar alcohol particles that are not granulated sugar alcohol particles having a particle size with more than 80% of the particles being below 500 microns, and wherein a Hausner ratio of the dissolvable unstamped powder delivery system is between 1.00 and 1.45.
Dependencies are inferred from the claim text.