Zwitterionic polymer particle compositions and related methods

A composition for oral and/or mucosal administration of a biologically active agent, comprising:

• a plurality of particles, wherein each particle has an exterior surface, the exterior surface defining a particle interior, the exterior surface having at least one type of zwitterionic polymer disposed thereon and/or extending therefrom, wherein the zwitterionic polymer is a copolymer with a lipid-derived polymer, wherein the copolymer comprises a copolymer selected from the group consisting of:
• PCBMA-PODA, PCBOH-PODA, PSBMA-PODA, PCAR-PODA, PMPC-PODA;
• a biologically active agent disposed on the exterior surface and/or in the particle interior, wherein the biologically active agent comprises an antidiabetic agent which is a protein or peptide;
• and
• an additive effective to aggregate and/or condense, and/or insolubilize the biologically active agent;
• wherein the plurality of particles is lyophilized and wherein the lyophilized plurality of particles is in an oral formulation comprising an enteric coating.