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US 12,551,407 B2Granted
System for molding and coating of pharmaceutical tablets
AssigneesContinuus Pharmaceuticals, Inc., I.M.A Industria Macchine Autommatiche S.p.A.
InventorsBhakti Halkude, Federica Casati, Evan James Goodwin, Saptarshi Chattopadhyay, Bayan Teisho Takizawa, Salvatore Mascia
Life of this patent
Estimating the term…
Abstract
Disclosed herein are new injection molding-coating devices for the continuous manufacturing of coated pharmaceutical tablets comprising one or more active pharmaceutical ingredients and one or more excipients. Also disclosed herein are methods for the continuous manufacture of coated pharmaceutical tablets using these new devices for the purpose application in the pharmaceutical and drug manufacturing industries.
Claims21
A machine for producing coated pharmaceutical tablets by a continuous process comprising:
- a mold unit (200) comprising a molding frame (207) comprising at least one core block (500) and rotatable to at least four positions;
- a first coating delivery system (400A) comprising a first cavity block (600), a means to provide a heated coating material under pressure, and a mechanism for reversibly joining and placing said first cavity block in fluid communication with said at least one core block (500) forming a first temporary mold on said molding frame (207) at a first position;
- a core injection unit (300) comprising a piston barrel injection chamber (325) fitted with a retractable piston (321), a port, a second cavity block (700), and a mechanism for reversibly joining and placing said second cavity block (700) in fluid communication with said at least one core block forming a second temporary mold on said molding frame (207) at a second position, wherein said retractable piston (321) is configured to retract to expand said piston barrel injection chamber (325) and extend to eject material present in said piston barrel injection chamber (325) into said second temporary mold;
- a second coating delivery system (400B) comprising a third cavity block (800), a means to provide a heated coating material under pressure, and a mechanism for reversibly joining and placing said third cavity block (800) in fluid communication with said at least one core block (500) forming a third temporary mold on said molding frame (207) at a third position;
- and
- a discharge area located at or in proximity to a fourth position of said molding frame (207), wherein said at least one core block (500) comprises a plurality of wells (502) on its surface, wherein said first cavity block (600) comprises a plurality of extrusions (602) extending out from its surface, and wherein each of said second cavity block (700) and said third cavity block (800) comprises a plurality of wells (702) on its surface.
3 more elements
A machine for producing coated pharmaceutical tablets by a continuous process comprising:
- a mold unit (200) comprising a molding frame (207) comprising at least one core block (500) and rotatable to at least four positions;
- a coating delivery system (400) comprising a first cavity block (600) and a third cavity block (800), a means to provide a heated coating material under pressure, and a mechanism for reversibly joining and placing either said first cavity block (600) or said third cavity block (800) in fluid communication with said at least one core block (500) forming a temporary mold on said molding frame (207) at either a first or third position;
- a core injection unit (300) comprising a piston barrel injection chamber (325) fitted with a retractable piston (321), a port, a second cavity block (700), and a mechanism for reversibly joining and placing said second cavity block in fluid communication with said at least one core block (500) forming a temporary mold on said molding frame (207) at a second position, wherein said retractable piston (321) is configured to retract to expand said piston barrel injection chamber (325) and extend to eject material present in said piston barrel injection chamber (325) into said second temporary mold;
- and
- a discharge area located at or in proximity to a fourth position of said molding frame (207),
- wherein said at least one core block (500) comprises a plurality of wells (502) on its surface, wherein said first cavity block (600) comprises a plurality of extrusions (602) extending out from its surface, and wherein each of said second cavity block (700) and said third cavity block (800) comprises a plurality of wells (702) on its surface.
3 more elements
A machine for producing uncoated pharmaceutical tablets by a continuous process comprising:
- a mold unit (200) comprising a molding frame (207) at least one core block (500) and rotatable to at least four positions;
- a core injection unit comprising a piston barrel injection chamber (325) fitted with a retractable piston (321), a port, a cavity block (700), and a mechanism for reversibly joining and placing said cavity block in fluid communication with said at least one core block (500) forming a temporary mold on said molding frame (207) at a first, second, or third position, wherein said retractable piston (321) is configured to retract to expand said piston barrel injection chamber (325) and extend to eject material present in said piston barrel injection chamber (325) into said second temporary mold;
- and
- a discharge area located at or in proximity to a fourth position of said molding frame (207),
- wherein said at least one core block (500) comprises a plurality of wells (502) on its surface, and wherein said cavity block (700) comprises a plurality of wells (702) on its surface.
2 more elements
Dependencies are inferred from the claim text.