US 12,551,173 B2 · System and method for single-scan rest-stress cardiac PET

Abstract

The present invention provides a system and method for performing a single-scan rest-stress cardiac measurement. In one aspect, the system includes a positron emission tomography (PET) imaging system, a source of a first PET radiotracer for administration to a subject, a source of a second PET radiotracer for administration to a subject, and a processor. The processor has non-transient computer readable media programmed with instructions to obtain PET images of the subject administered with the radiotracer. Furthermore, the computer readable media is programmed with instructions to process the PET images with a non-steady-state, multi-compartment parametric model. An output of the non-steady-state, multi-compartment parametric model is a measure of myocardial blood flow for both a rest state and a stress state of the subject.

Claims16

Dependent claims

A method for determining myocardial blood flow using single-scan rest-stress positron emission tomography (PET), the method comprising:

receiving PET imaging data acquired from a subject during a single scan session using a PET system, a rest state radiotracer administered to the subject during a rest state of the single scan session, and a stress state radiotracer administered to the subject during a stress state of the single scan session;
generating, using a processor, images of the subject from the PET imaging data;
processing, using the processor, the images using a model comprising a single input function for the rest state radiotracer and the stress state radiotracer, and at least one time-varying transport rate configured to account for effects of pharmacological stress during the stress state on both the rest state radiotracer and the stress state radiotracer;
and
generating, using the processor, a report comprising an output of the model indicating a measure of a myocardial blood flow for both the rest state and the stress state.

2 more elements

Dependencies are inferred from the claim text.

System and method for single-scan rest-stress cardiac PET

Life of this patent

System and method for single-scan rest-stress cardiac PET

Life of this patent

Abstract

Claims16