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US 12,546,786 B2Granted
Circulatory biomarkers for placental or fetal health
AssigneeThe University of Melbourne
InventorsStephen Tong, Tu'uhevaha Joy Lino, Teresa Mary MacDonald, Susan Philippa Walker
Life of this patent
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Abstract
Disclosed are assays, protocols and reagents to facilitate clinical management of pregnancy with improved pre- and post-natal health outcomes for fetuses developing in an environment of placental insufficiency.
Claims8
A method of treating a pregnant human subject carrying a small for gestational age (SGA) fetus or a fetus with fetal growth restriction (FGR), said method comprising:
- (a) obtaining a sample of whole blood, plasma, or serum from a pregnant human subject that is at least 15 weeks gestation;
- (b) incubating the sample with an antibody that binds to maternal SPINT1 protein to determine the level of circulating maternal SPINT1;
- (c) determining that the pregnant human subject is carrying a SGA fetus or a fetus with FGR when the level of circulating maternal SPINT1 protein is (i) decreased relative to a control level that is representative of a level of circulating maternal SPINT1 protein in a pregnant human subject with adequate placental sufficiency, or (ii) has decreased over time;
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- (d) treating the pregnant human subject carrying a SGA fetus or fetus with FGR by pre-term delivery of the fetus.
2 more elements
Dependencies are inferred from the claim text.