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US 12,545,957 B2Granted
Method of determining endometrial receptivity and application thereof
AssigneeYikon Genomics (Suzhou) Co., Ltd.
InventorsChunxu Hu, Yanping Li, Xin Dong, Sijia Lu, Mintao Hu
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for determining endometrial receptivity and an application thereof. Specifically, the present invention provides a method for determining endometrial receptivity and markers for determining an endometrial receptivity status. The markers of the present invention could greatly reduce the error rate during the determination of the endometrial receptivity.
Claims6
A method for embryo implantation into a woman undergoing in vitro fertilization (IVF), comprising the following steps:
- (a) obtaining a sample of endometrial tissues, uterine fluid, and/or vaginal exfoliated cells, wherein the sample is from the following periods:
- LH+5 to LH+9, preferably, LH+7;
- (b) measuring the mRNA expression levels of endometrial receptivity-related genes in the sample;
- (c) determining that the endometrium is receptive by either comparing the mRNA expression levels of the endometrial receptivity-related genes obtained in the step (b) with a predetermined value of the expression levels of said genes in a pre-receptivity period, intermediate period, and a post-receptivity period or inputting the mRNA expression levels of the endometrial receptivity-related genes obtained in the step (b) into an analysis model for determining endometrial receptivity constructed by a supervised learning method;
- and
- (d) implanting an embryo into said woman,
- wherein the endometrial receptivity-related genes are differentially-expressed in the pre-receptivity period, intermediate period, and the post-receptivity period, and comprise all 634 genes of Table A
- TABLE A
- Name
- 1
- KRIT1
- 2
- RBM5
- 3
- PAF1
- 4
- RFC1
- 5
- TPR
- 6
- ACAA1
- 7
- SFSWAP
- 8
- SPEN
- 9
- CPSF1
- 10
- XRCC1
- 11
- KDM5A
- 12
- SART3
- 13
- PIK3C3
- 14
- YTHDC1
- 15
- PPIE
- 16
- NFX1
- 17
- CDC5L
- 18
- SF3A1
- 19
- TXN2
- 20
- EIF3D
- 21
- EP300
- 22
- CHD8
- 23
- PNN
- 24
- CSTF1
- 25
- PRPF6
- 26
- PQBP1
- 27
- CIAO3
- 28
- HMOX2
- 29
- PIH1D1
- 30
- AKAP8
- 31
- BUD31
- 32
- EIF3A
- 33
- CASC3
- 34
- CDK5RAP3
- 35
- SUPT6H
- 36
- CNOT2
- 37
- SUDS3
- 38
- TBCCD1
- 39
- EIF2B4
- 40
- ORC2
- 41
- SRSF4
- 42
- SFPQ
- 43
- SRSF11
- 44
- PRRC2C
- 45
- FBXW2
- 46
- SNX19
- 47
- EPC1
- 48
- TBCC
- 49
- CNOT1
- 50
- GTF2F1
- 51
- KDM5C
- 52
- NSRP1
- 53
- UXT
- 54
- ATG14
- 55
- AKAP9
- 56
- PRKRIP1
- 57
- CCNT1
- 58
- LSM4
- 59
- RLIM
- 60
- ERAL1
- 61
- PTPRA
- 62
- NASP
- 63
- SRRM1
- 64
- PRPF38A
- 65
- CDK5RAP2
- 66
- PRPF4
- 67
- PPIG
- 68
- SMARCC2
- 69
- TCF25
- 70
- CSNKID
- 71
- ENSA
- 72
- TEX261
- 73
- FIP1L1
- 74
- CENPC
- 75
- ZMAT2
- 76
- CELF1
- 77
- CPSF7
- 78
- UPF2
- 79
- MMS19
- 80
- SON
- 81
- ADAR
- 82
- MAGOH
- 83
- ELP6
- 84
- NIPBL
- 85
- SLU7
- 86
- PCF11
- 87
- NSD1
- 88
- YWHAB
- 89
- DDB1
- 90
- SF1
- 91
- ATG4B
- 92
- FEM1B
- 93
- SIN3A
- 94
- LUZP1
- 95
- GPS1
- 96
- SF3B5
- 97
- HNRNPA3
- 98
- PYM1
- 99
- RBM4
- 100
- PRPF8
- 101
- ZBTB4
- 102
- CKAP5
- 103
- SMAD2
- 104
- POLR2A
- 105
- RNF135
- 106
- RNF41
- 107
- MRPS11
- 108
- CEP63
- 109
- EIF3C
- 110
- SF3B3
- 111
- SIAH1
- 112
- SND1
- 113
- UBL5
- 114
- NELFE
- 115
- EIF3CL
- 116
- FIS1
- 117
- TRIM26
- 118
- MRPL20
- 119
- KMT2E
- 120
- AFF4
- 121
- GTF3C1
- 122
- ANAPC5
- 123
- MAEA
- 124
- TOX4
- 125
- GID8
- 126
- ARFGAP1
- 127
- ARHGEF7
- 128
- H2AFV
- 129
- ZNHIT1
- 130
- COA1
- 131
- GBF1
- 132
- GOSR1
- 133
- IFT20
- 134
- ANAPC15
- 135
- IK
- 136
- KANSL3
- 137
- GTF3C2
- 138
- CHMP3
- 139
- FAM20B
- 140
- CHCHD5
- 141
- RPAIN
- 142
- UBE4B
- 143
- C19orf12
- 144
- ANKRD17
- 145
- MED6
- 146
- TMEM258
- 147
- ERCC5
- 148
- ATP5MC2
- 149
- SMPD4
- 150
- ECPAS
- 151
- DMAC1
- 152
- SEC24B
- 153
- NCOR1
- 154
- PI4KB
- 155
- Clorf43
- 156
- ASXL2
- 157
- VTI1A
- 158
- PPP1R15B
- 159
- SNF8
- 160
- GATD3A
- 161
- MED11
- 162
- RAD21
- 163
- SPIDR
- 164
- ANAPC16
- 165
- VPS39
- 166
- ATP5PD
- 167
- FIBP
- 168
- CORO1B
- 169
- RAB1B
- 170
- RMDN1
- 171
- BETIL
- 172
- ASB8
- 173
- EXOC7
- 174
- UQCR10
- 175
- TOP1
- 176
- SPOUT1
- 177
- ARMCX6
- 178
- PPP1R10
- 179
- LIN52
- 180
- SMIM7
- 181
- TOMM6
- 182
- PDCD6
- 183
- GGNBP2
- 184
- GATD3B
- 185
- KIAA0100
- 186
- ELOA
- 187
- AQR
- 188
- FBXO42
- 189
- LSG1
- 190
- FAM120A
- 191
- THRAP3
- 192
- ARID4B
- 193
- POLR3E
- 194
- GPBP1
- 195
- RFXANK
- 196
- TAF11
- 197
- BUD23
- 198
- PDCD2
- 199
- BCS1L
- 200
- ZNF638
- 201
- ZNF37A
- 202
- EXOSC7
- 203
- TOP2B
- 204
- DELE1
- 205
- GCN1
- 206
- DDX24
- 207
- DHPS
- 208
- WAC
- 209
- HPS4
- 210
- PPP6R2
- 211
- PACSIN2
- 212
- HMGXB4
- 213
- POLR3H
- 214
- RBM23
- 215
- ZC3H14
- 216
- DCAF11
- 217
- NDRG3
- 218
- GYS1
- 219
- CCDC130
- 220
- DNAJC2
- 221
- CHCHD2
- 222
- TMEM248
- 223
- NUFIP2
- 224
- UBTF
- 225
- MTMR4
- 226
- RSRC2
- 227
- KRR1
- 228
- CHD4
- 229
- ZNF451
- 230
- SENP6
- 231
- PRPF4B
- 232
- PRKAR2A
- 233
- FXR1
- 234
- HDLBP
- 235
- PPP1R7
- 236
- ASHIL
- 237
- GON4L
- 238
- TSNAX
- 239
- HMGCL
- 240
- MED28
- 241
- NEK9
- 242
- PANK3
- 243
- SPOP
- 244
- MTIF3
- 245
- ZC3H13
- 246
- SMUG1
- 247
- RAB22A
- 248
- STAU1
- 249
- DDX27
- 250
- SERPINB6
- 251
- MEA1
- 252
- COX6B1
- 253
- TIMM17B
- 254
- XPO7
- 255
- SAFB2
- 256
- EIF2S3
- 257
- UBA1
- 258
- RBM39
- 259
- ACLY
- 260
- DHX30
- 261
- SCO1
- 262
- LARS
- 263
- PPHLN1
- 264
- LPIN1
- 265
- TIMM10
- 266
- ARGLU1
- 267
- TFCP2
- 268
- C2orf49
- 269
- SLTM
- 270
- CIR1
- 271
- TMOD3
- 272
- SBNO1
- 273
- DCAF5
- 274
- ANP32A
- 275
- COMMD4
- 276
- ARHGAP17
- 277
- RHOT2
- 278
- SERBP1
- 279
- STRIP1
- 280
- UFC1
- 281
- MRPL9
- 282
- UBAP2L
- 283
- SDE2
- 284
- SNRNP200
- 285
- C7orf50
- 286
- MDH2
- 287
- NDUFB11
- 288
- TAF1
- 289
- EIF4EBP2
- 290
- MTG1
- 291
- NUDT22
- 292
- VIPAS39
- 293
- KIN
- 294
- ATP5F1A
- 295
- PELO
- 296
- SAR1B
- 297
- HNRNPDL
- 298
- CCDC174
- 299
- LARP1
- 300
- SCAF4
- 301
- APPL 1
- 302
- GPBP1L1
- 303
- PSKH1
- 304
- SSU72
- 305
- CCDC12
- 306
- ZYG11B
- 307
- PMVK
- 308
- KIAA1143
- 309
- UBXN7
- 310
- GAPVD1
- 311
- NEMF
- 312
- HIF1AN
- 313
- MARF1
- 314
- NDUFV1
- 315
- HARS
- 316
- ATF7
- 317
- AKAP13
- 318
- QARS
- 319
- ZNF24
- 320
- FAM192A
- 321
- MRPL57
- 322
- CHD2
- 323
- TOMM20
- 324
- MGA
- 325
- IP6K1
- 326
- DNAJC30
- 327
- IMP3
- 328
- NDUFAF3
- 329
- SPTY2D1
- 330
- CLK3
- 331
- MRPS23
- 332
- TTC3
- 333
- GPATCH8
- 334
- USP7
- 335
- LAMTOR4
- 336
- TBC1D9B
- 337
- GSTK1
- 338
- QRICH1
- 339
- DDX39B
- 340
- GIGYF2
- 341
- BRD2
- 342
- GPANK1
- 343
- PRRC2A
- 344
- DHX16
- 345
- NAP1L4
- 346
- SELENOH
- 347
- RBMXL1
- 348
- ACBD6
- 349
- FAM133B
- 350
- CDKN2AIPNL
- 351
- CDK11B
- 352
- PRKDC
- 353
- MYO19
- 354
- LASIL
- 355
- PPP1R12A
- 356
- CCAR1
- 357
- SMC1A
- 358
- ARAF
- 359
- HSP90AA1
- 360
- CHERP
- 361
- SRRT
- 362
- SF3B2
- 363
- HNRNPC
- 364
- HNRNPM
- 365
- RBX1
- 366
- TELO2
- 367
- UBE2I
- 368
- TIMM50
- 369
- PRPF31
- 370
- TCERG1
- 371
- TUSC2
- 372
- EIF4G1
- 373
- NCL
- 374
- PRPF3
- 375
- SNRPB
- 376
- PRKCSH
- 377
- TUBGCP2
- 378
- EIF3G
- 379
- SYNCRIP
- 380
- HUS1
- 381
- ACTRIA
- 382
- MBD1
- 383
- HDGF
- 384
- PARP1
- 385
- RPL7L1
- 386
- RPUSD3
- 387
- ACOX1
- 388
- U2SURP
- 389
- CPSF2
- 390
- TSR1
- 391
- RFWD3
- 392
- CD2BP2
- 393
- PCBP1
- 394
- PA2G4
- 395
- PPID
- 396
- HCFC1
- 397
- FKBP2
- 398
- BRMS1
- 399
- EIF3K
- 400
- PUF60
- 401
- NOC2L
- 402
- PRPF40A
- 403
- RNPS1
- 404
- DCP1A
- 405
- CWC25
- 406
- MED24
- 407
- PHF20
- 408
- EIPR1
- 409
- KAT6A
- 410
- PSMD8
- 411
- NOP56
- 412
- COPE
- 413
- SSR3
- 414
- COPA
- 415
- THOC6
- 416
- WDR74
- 417
- PSMB7
- 418
- HAX1
- 419
- SURF6
- 420
- VPS28
- 421
- VKORC1
- 422
- PSMD13
- 423
- TMEM222
- 424
- C6orf106
- 425
- MRPL38
- 426
- CSNK2B
- 427
- PSMB3
- 428
- CCDC124
- 429
- RANBP3
- 430
- NOP58
- 431
- ZFR
- 432
- IDH3G
- 433
- HSD17B10
- 434
- MRPL28
- 435
- PSMC5
- 436
- HSP90AB1
- 437
- L3MBTL2
- 438
- CINP
- 439
- NAA10
- 440
- SGTA
- 441
- EDF1
- 442
- NDUFS8
- 443
- TPI1
- 444
- MFN2
- 445
- DNPEP
- 446
- CLPP
- 447
- RBM42
- 448
- PNKD
- 449
- ILF3
- 450
- COX4I1
- 451
- RBSN
- 452
- ILKAP
- 453
- NIP7
- 454
- THUMPD3
- 455
- CCT7
- 456
- TBRG4
- 457
- DDX56
- 458
- DCAF7
- 459
- YME1L1
- 460
- MAN2C1
- 461
- SCYL1
- 462
- GPN2
- 463
- GMPPA
- 464
- DDX46
- 465
- SRFBP1
- 466
- CXXC1
- 467
- EIF5B
- 468
- GPATCH4
- 469
- EIF4A1
- 470
- UBXN1
- 471
- IWS1
- 472
- PSMC3
- 473
- CIAO2B
- 474
- ZNF592
- 475
- DNAJC7
- 476
- DTYMK
- 477
- RNF181
- 478
- SLC25A6
- 479
- TRMT112
- 480
- EIF1AD
- 481
- AURKAIP1
- 482
- ACSF3
- 483
- TALDO1
- 484
- COX5A
- 485
- TUFM
- 486
- FARSA
- 487
- MRPL14
- 488
- ARL6IP4
- 489
- EWSR1
- 490
- DDX41
- 491
- CDK10
- 492
- FAAP100
- 493
- RPS19BP1
- 494
- PTMA
- 495
- MRPL21
- 496
- MRPS18B
- 497
- ABCF1
- 498
- MCRIP1
- 499
- CNPY2
- 500
- MRPL12
- 501
- BAZ2A
- 502
- USP4
- 503
- SMG7
- 504
- ARPP19
- 505
- NR1H2
- 506
- NPEPPS
- 507
- BIN3
- 508
- UBE3B
- 509
- WASF2
- 510
- TAGLN2
- 511
- IRF2
- 512
- RELA
- 513
- DCTN2
- 514
- CIB1
- 515
- SPTAN1
- 516
- WWP2
- 517
- MSRB1
- 518
- DCTN1
- 519
- EIF6
- 520
- CUX1
- 521
- WDR1
- 522
- PDRG1
- 523
- SH3GLB1
- 524
- SNAP29
- 525
- KLHDC3
- 526
- CHMP1A
- 527
- LGALS3
- 528
- GLYR1
- 529
- NOSIP
- 530
- HERC4
- 531
- UBE2J2
- 532
- CHTOP
- 533
- PEF1
- 534
- ZDHHC3
- 535
- ATP5MD
- 536
- SETD3
- 537
- MCRS1
- 538
- AP1G2
- 539
- CHMP1B
- 540
- ARF5
- 541
- RNF10
- 542
- SNX1
- 543
- HAGH
- 544
- FAM50A
- 545
- MYL6
- 546
- NANS
- 547
- LPIN2
- 548
- UBL4A
- 549
- TBCB
- 550
- PRKD2
- 551
- DMAC2
- 552
- RNF7
- 553
- WRAP73
- 554
- PEX16
- 555
- ANXA11
- 556
- CYREN
- 557
- DYNLRB1
- 558
- HECTD3
- 559
- PGLS
- 560
- COX5B
- 561
- CDK9
- 562
- ARPC5L
- 563
- RTCA
- 564
- UNC45A
- 565
- NARF
- 566
- GUK1
- 567
- CAST
- 568
- NIT1
- 569
- EFCAB14
- 570
- PRMT2
- 571
- FLAD1
- 572
- SLMAP
- 573
- TKT
- 574
- SLFN5
- 575
- CSNKIG1
- 576
- EXOSC10
- 577
- NADSYN1
- 578
- KDM2A
- 579
- KPNA4
- 580
- TMEM120A
- 581
- COX19
- 582
- ARPIN
- 583
- SYNRG
- 584
- LYPLA2
- 585
- TOLLIP
- 586
- CDC37
- 587
- H2AFY
- 588
- RBCK1
- 589
- RAF1
- 590
- GPS2
- 591
- NMT1
- 592
- FLOT1
- 593
- FBXW5
- 594
- SQSTM1
- 595
- DTX3L
- 596
- PPIA
- 597
- SMG5
- 598
- EGLN2
- 599
- ROCK1
- 600
- PXN
- 601
- RANGAP1
- 602
- PSMA7
- 603
- MBD4
- 604
- ADRM1
- 605
- ARF3
- 606
- SMIM12
- 607
- PPPICA
- 608
- SMIM29
- 609
- WDR5
- 610
- GRIPAP1
- 611
- CWF19L1
- 612
- MED15
- 613
- TSPO
- 614
- MYH9
- 615
- ITPK1
- 616
- TPD52L2
- 617
- GSDMD
- 618
- PSMD9
- 619
- ADPRHL2
- 620
- CCDC32
- 621
- NSUN5
- 622
- EIF4E2
- 623
- MGST3
- 624
- PCYTIA
- 625
- SAP30BP
- 626
- RNASEK-C17orf49
- 627
- SHISA5
- 628
- BLCAP
- 629
- DDX23
- 630
- FLII
- 631
- GAK
- 632
- PAK2
- 633
- HGS
- 634
- AATF.
1,274 more elements
A method for embryo transplantation to a human under test, comprising the following steps:
- (1) obtaining a sample derived from the human under test and detecting the mRNA expression level of each biomarker in the set of the sample, wherein, the set comprises all 634 genes of Table A,
- wherein the sample is a sample of endometrial tissues, uterine fluid, and/or vaginal exfoliated cells, and the sample is from the following periods:
- LH+5 to LH+9, preferably, LH+7,
- and the biomarkers are differentially-expressed in a pre-receptivity period, an intermediate period, and a post-receptivity period;
- (2) determining that the endometrium is receptive by either comparing the level detected in step (1) with a predetermined value of the expression levels of said genes in the pre-receptivity period, intermediate period, and the post-receptivity period or inputting the level detected in step (1) into an analysis model for determining endometrial receptivity constructed by a supervised learning method;
- and
- (3) transplanting an embryo into said human under test,
- TABLE A
- Name
- 1
- KRIT1
- 2
- RBM5
- 3
- PAF1
- 4
- RFC1
- 5
- TPR
- 6
- ACAA1
- 7
- SFSWAP
- 8
- SPEN
- 9
- CPSF1
- 10
- XRCC1
- 11
- KDM5A
- 12
- SART3
- 13
- PIK3C3
- 14
- YTHDC1
- 15
- PPIE
- 16
- NFX1
- 17
- CDC5L
- 18
- SF3A1
- 19
- TXN2
- 20
- EIF3D
- 21
- EP300
- 22
- CHD8
- 23
- PNN
- 24
- CSTF1
- 25
- PRPF6
- 26
- PQBP1
- 27
- CIAO3
- 28
- HMOX2
- 29
- PIH1D1
- 30
- AKAP8
- 31
- BUD31
- 32
- EIF3A
- 33
- CASC3
- 34
- CDK5RAP3
- 35
- SUPT6H
- 36
- CNOT2
- 37
- SUDS3
- 38
- TBCCD1
- 39
- EIF2B4
- 40
- ORC2
- 41
- SRSF4
- 12
- SFPQ
- 43
- SRSF11
- 44
- PRRC2C
- 45
- FBXW2
- 46
- SNX19
- 47
- EPC1
- 48
- TBCC
- 49
- CNOT1
- 50
- GTF2F1
- 51
- KDM5C
- 52
- NSRP1
- 53
- UXT
- 54
- ATG14
- 55
- AKAP9
- 56
- PRKRIP1
- 57
- CCNT1
- 58
- LSM4
- 59
- RLIM
- 60
- ERAL1
- 61
- PTPRA
- 62
- NASP
- 63
- SRRM1
- 64
- PRPF38A
- 65
- CDK5RAP2
- 66
- PRPF4
- 67
- PPIG
- 68
- SMARCC2
- 69
- TCF25
- 70
- CSNK1D
- 71
- ENSA
- 72
- TEX261
- 73
- FIP1L1
- 74
- CENPC
- 75
- ZMAT2
- 76
- CELF1
- 77
- CPSF7
- 78
- UPF2
- 79
- MMS19
- 80
- SON
- 81
- ADAR
- 82
- MAGOH
- 83
- ELP6
- 84
- NIPBL
- 85
- SLU7
- 86
- PCF11
- 87
- NSD1
- 88
- YWHAB
- 89
- DDB1
- 90
- SF1
- 91
- ATG4B
- 92
- FEM1B
- 93
- SIN3A
- 94
- LUZP1
- 95
- GPS1
- 96
- SF3B5
- 97
- HNRNPA3
- 98
- PYM1
- 99
- RBM4
- 100
- PRPF8
- 101
- ZBTB4
- 102
- CKAP5
- 103
- SMAD2
- 104
- POLR2A
- 105
- RNF135
- 106
- RNF41
- 107
- MRPS11
- 108
- CEP63
- 109
- EIF3C
- 110
- SF3B3
- 111
- SIAH1
- 112
- SND1
- 113
- UBL5
- 114
- NELFE
- 115
- EIF3CL
- 116
- FIS1
- 117
- TRIM26
- 118
- MRPL20
- 119
- KMT2E
- 120
- AFF4
- 121
- GTF3C1
- 122
- ANAPC5
- 123
- MAEA
- 124
- TOX4
- 125
- GID8
- 126
- ARFGAP1
- 127
- ARHGEF7
- 128
- H2AFV
- 129
- ZNHIT1
- 130
- COA1
- 131
- GBF1
- 132
- GOSR1
- 133
- IFT20
- 134
- ANAPC15
- 135
- IK
- 136
- KANSL3
- 137
- GTF3C2
- 138
- CHMP3
- 139
- FAM20B
- 140
- CHCHD5
- 141
- RPAIN
- 142
- UBE4B
- 143
- C19orf12
- 144
- ANKRD17
- 145
- MED6
- 146
- TMEM258
- 147
- ERCC5
- 148
- ATP5MC2
- 149
- SMPD4
- 150
- ECPAS
- 151
- DMAC1
- 152
- SEC24B
- 153
- NCOR1
- 154
- PI4KB
- 155
- C1orf43
- 156
- ASXL2
- 157
- VTI1A
- 158
- PPP1R15B
- 159
- SNF8
- 160
- GATD3A
- 161
- MED11
- 162
- RAD21
- 163
- SPIDR
- 164
- ANAPC16
- 165
- VPS39
- 166
- ATP5PD
- 167
- FIBP
- 168
- CORO1B
- 169
- RAB1B
- 170
- RMDN1
- 171
- BET1L
- 172
- ASB8
- 173
- EXOC7
- 174
- UQCR10
- 175
- TOP1
- 176
- SPOUT1
- 177
- ARMCX6
- 178
- PPP1R10
- 179
- LIN52
- 180
- SMIM7
- 181
- TOMM6
- 182
- PDCD6
- 183
- GGNBP2
- 184
- GATD3B
- 185
- KIAA0100
- 186
- ELOA
- 187
- AQR
- 188
- FBXO42
- 189
- LSG1
- 190
- FAM120A
- 191
- THRAP3
- 192
- ARID4B
- 193
- POLR3E
- 194
- GPBP1
- 195
- RFXANK
- 196
- TAF11
- 197
- BUD23
- 198
- PDCD2
- 199
- BCS1L
- 200
- ZNF638
- 201
- ZNF37A
- 202
- EXOSC7
- 203
- TOP2B
- 204
- DELE1
- 205
- GCN1
- 206
- DDX24
- 207
- DHPS
- 208
- WAC
- 209
- HPS4
- 210
- PPP6R2
- 211
- PACSIN2
- 212
- HMGXB4
- 213
- POLR3H
- 214
- RBM23
- 215
- ZC3H14
- 216
- DCAF11
- 217
- NDRG3
- 218
- GYS1
- 219
- CCDC130
- 220
- DNAJC2
- 221
- CHCHD2
- 222
- TMEM248
- 223
- NUFIP2
- 224
- UBTF
- 225
- MTMR4
- 226
- RSRC2
- 227
- KRR1
- 228
- CHD4
- 229
- ZNF451
- 230
- SENP6
- 231
- PRPF4B
- 232
- PRKAR2A
- 233
- FXR1
- 234
- HDLBP
- 235
- PPP1R7
- 236
- ASH1L
- 237
- GON4L
- 238
- TSNAX
- 239
- HMGCL
- 240
- MED28
- 241
- NEK9
- 242
- PANK3
- 243
- SPOP
- 244
- MTIF3
- 245
- ZC3H13
- 246
- SMUG1
- 247
- RAB22A
- 248
- STAU1
- 249
- DDX27
- 250
- SERPINB6
- 251
- MEA1
- 252
- COX6B1
- 253
- TIMM17B
- 254
- XPO7
- 255
- SAFB2
- 256
- EIF2S3
- 257
- UBA1
- 258
- RBM39
- 259
- ACLY
- 260
- DHX30
- 261
- SCO1
- 262
- LARS
- 263
- PPHLN1
- 264
- LPIN1
- 265
- TIMM10
- 266
- ARGLU1
- 267
- TFCP2
- 268
- C2orf49
- 269
- SLTM
- 270
- CIR1
- 271
- TMOD3
- 272
- SBNO1
- 273
- DCAF5
- 274
- ANP32A
- 275
- COMMD4
- 276
- ARHGAP17
- 277
- RHOT2
- 278
- SERBP1
- 279
- STRIP1
- 280
- UFC1
- 281
- MRPL9
- 282
- UBAP2L
- 283
- SDE2
- 284
- SNRNP200
- 285
- C7orf50
- 286
- MDH2
- 287
- NDUFB[11
- 288
- TAF1
- 289
- EIF4EBP2
- 290
- MTG1
- 291
- NUDT22
- 292
- VIPAS39
- 293
- KIN
- 294
- ATPSF1A
- 295
- PELO
- 296
- SAR1B
- 297
- HNRNPDL
- 298
- CCDC174
- 299
- LARP1
- 300
- SCAF4
- 301
- APPL1
- 302
- GPBP1L1
- 303
- PSKH1
- 304
- SSU72
- 305
- CCDC12
- 306
- ZYG11B
- 307
- PMVK
- 308
- KIAA1143
- 309
- UBXN7
- 310
- GAPVD1
- 311
- NEMF
- 312
- HIF1AN
- 313
- MARF1
- 314
- NDUFV1
- 315
- HARS
- 316
- ATF7
- 317
- AKAP13
- 318
- QARS
- 319
- ZNF24
- 320
- FAM192A
- 321
- MRPL57
- 322
- CHD2
- 323
- TOMM20
- 324
- MGA
- 325
- IP6K1
- 326
- DNAJC30
- 327
- IMP3
- 328
- NDUFAF3
- 329
- SPTY2D1
- 330
- CLK3
- 331
- MRPS23
- 332
- TTC3
- 333
- GPATCH8
- 334
- USP7
- 335
- LAMTOR4
- 336
- TBC1D9B
- 337
- GSTK1
- 338
- QRICH1
- 339
- DDX39B
- 340
- GIGYF2
- 341
- BRD2
- 342
- GPANK1
- 343
- PRRC2A
- 344
- DHX16
- 345
- NAP1L4
- 346
- SELENOH
- 347
- RBMXL1
- 348
- ACBD6
- 349
- FAM133B
- 350
- CDKN2AIPNL
- 351
- CDK11B
- 352
- PRKDC
- 353
- MYO19
- 354
- LAS1L
- 355
- PPP1R12A
- 356
- CCAR1
- 357
- SMC1A
- 358
- ARAF
- 359
- HSP90AA1
- 360
- CHERP
- 361
- SRRT
- 362
- SF3B2
- 363
- HNRNPC
- 364
- HNRNPM
- 365
- RBX1
- 366
- TELO2
- 367
- UBE2I
- 368
- TIMM50
- 369
- PRPF31
- 370
- TCERG1
- 371
- TUSC2
- 372
- EIF4G1
- 373
- NCL
- 374
- PRPF3
- 375
- SNRPB
- 376
- PRKCSH
- 377
- TUBGCP2
- 378
- EIF3G
- 379
- SYNCRIP
- 380
- HUS1
- 381
- ACTR1A
- 382
- MBD1
- 383
- HDGF
- 384
- PARP1
- 385
- RPL7L1
- 386
- RPUSD3
- 387
- ACOX1
- 388
- U2SURP
- 389
- CPSF2
- 390
- TSR1
- 391
- RFWD3
- 392
- CD2BP2
- 393
- PCBP1
- 394
- PA2G4
- 395
- PPID
- 396
- HCFC1
- 397
- FKBP2
- 398
- BRMS1
- 399
- EIF3K
- 400
- PUF60
- 401
- NOC2L
- 402
- PRPF40A
- 403
- RNPS1
- 404
- DCP1A
- 405
- CWC25
- 406
- MED24
- 407
- PHF20
- 408
- EIPR1
- 409
- KAT6A
- 410
- PSMD8
- 411
- NOP56
- 412
- COPE
- 413
- SSR3
- 414
- COPA
- 415
- THOC6
- 416
- WDR74
- 417
- PSMB7
- 418
- HAX1
- 419
- SURF6
- 420
- VPS28
- 421
- VKORC1
- 422
- PSMD13
- 423
- TMEM222
- 424
- C6orf106
- 425
- MRPL38
- 426
- CSNK2B
- 427
- PSMB3
- 428
- CCDC124
- 429
- RANBP3
- 430
- NOP58
- 431
- ZFR
- 432
- IDH3G
- 433
- HSD17B10
- 434
- MRPL28
- 435
- PSMC5
- 436
- HSP90AB1
- 437
- L3MBTL2
- 438
- CINP
- 439
- NAA10
- 440
- SGTA
- 441
- EDF1
- 442
- NDUFS8
- 443
- TPI1
- 444
- MFN2
- 445
- DNPEP
- 446
- CLPP
- 447
- RBM42
- 448
- PNKD
- 449
- ILF3
- 450
- COX4I1
- 451
- RBSN
- 452
- ILKAP
- 453
- NIP7
- 454
- THUMPD3
- 455
- CCT7
- 456
- TBRG4
- 457
- DDX56
- 458
- DCAF7
- 459
- YME1L1
- 460
- MAN2C1
- 461
- SCYL1
- 462
- GPN2
- 463
- GMPPA
- 464
- DDX46
- 465
- SRFBP1
- 466
- CXXC1
- 467
- EIF5B
- 468
- GPATCH4
- 469
- EIF4A1
- 470
- UBXN1
- 471
- IWS
- 472
- PSMC3
- 473
- CIAO2B
- 474
- ZNF592
- 475
- DNAJC7
- 476
- DTYMK
- 477
- RNF181
- 478
- SLC25A6
- 479
- TRMT112
- 480
- EIF1AD
- 481
- AURKAIP1
- 482
- ACSF3
- 483
- TALDO1
- 484
- COX5A
- 485
- TUFM
- 486
- FARSA
- 487
- MRPL14
- 488
- ARL6IP4
- 489
- EWSR1
- 490
- DDX41
- 491
- CDK10
- 492
- FAAP100
- 493
- RPS19BP1
- 494
- PTMA
- 495
- MRPL21
- 496
- MRPS18B
- 497
- ABCF1
- 498
- MCRIP1
- 499
- CNPY2
- 500
- MRPL12
- 501
- BAZ2A
- 502
- USP4
- 503
- SMG7
- 504
- ARPP19
- 505
- NR1H2
- 506
- NPEPPS
- 507
- BIN3
- 508
- UBE3B
- 509
- WASF2
- 510
- TAGLN2
- 511
- IRF2
- 512
- RELA
- 513
- DCTN2
- 514
- CIB1
- 515
- SPTAN1
- 516
- WWP2
- 517
- MSRB1
- 518
- DCTN1
- 519
- FIF6
- 520
- CUX1
- 521
- WDR1
- 522
- PDRG1
- 523
- SH3GLB1
- 524
- SNAP29
- 525
- KLHDC3
- 526
- CHMP1A
- 527
- LGALS3
- 528
- GLYR1
- 529
- NOSIP
- 530
- HERC4
- 531
- UBE232
- 532
- CHTOP
- 533
- PEF1
- 534
- ZDHHC3
- 535
- ATP5MD
- 536
- SETD3
- 537
- MCRS1
- 538
- AP1G2
- 539
- CHMP1B
- 540
- ARF5
- 541
- RNF10
- 542
- SNX1
- 543
- HAGH
- 544
- FAM50A
- 545
- MYL6
- 546
- NANS
- 547
- LPIN2
- 548
- UBL4A
- 549
- TBCB
- 550
- PRKD2
- 551
- DMAC2
- 552
- RNF7
- 553
- WRAP73
- 554
- PEX16
- 555
- ANXA11
- 556
- CYREN
- 557
- DYNLRB1
- 558
- HECTD3
- 559
- POLS
- 560
- COX5B
- 561
- CDK9
- 562
- ARPC5L
- 563
- RTCA
- 564
- UNC45A
- 565
- NARF
- 566
- GUK1
- 567
- CAST
- 568
- NIT1
- 569
- EFCAB14
- 570
- PRMT2
- 571
- FLAD1
- 572
- SLMAP
- 573
- TKT
- 574
- SLFN5
- 575
- CSNK1G1
- 576
- EXOSC10
- 577
- NADSYN1
- 578
- KDM2A
- 579
- KPNA4
- 580
- TMEM120A
- 581
- COX19
- 582
- ARPIN
- 583
- SYNRG
- 584
- LYPLA2
- 585
- TOLLIP
- 586
- CDC37
- 587
- H2AFY
- 588
- RBCK1
- 589
- RAF1
- 590
- GPS2
- 591
- NMT1
- 592
- FLOT1
- 593
- FBXW5
- 594
- SQSTM1
- 595
- DTX3L
- 596
- PPIA
- 597
- SMG5
- 598
- EGLN2
- 599
- ROCK1
- 600
- PXN
- 601
- RANGAP1
- 602
- PSMA7
- 603
- MBD4
- 604
- ADRM1
- 605
- ARF3
- 606
- SMIM12
- 607
- PPP1CA
- 608
- SMIM29
- 609
- WDR5
- 610
- GRIPAP1
- 611
- CWF19L1
- 612
- MED15
- 613
- TSPO
- 614
- MYH9
- 615
- ITPK1
- 616
- TPD52L2
- 617
- GSDMD
- 618
- PSMD9
- 619
- ADPRHL2
- 620
- CCDC32
- 621
- NSUNS
- 622
- EIF4E2
- 623
- MGST3
- 624
- PCYT1A
- 625
- SAP30BP
- 626
- RNASEK-C17orf49
- 627
- SHISA5
- 628
- BLCAP
- 629
- DDX23
- 630
- FLII
- 631
- GAK
- 632
- PAK2
- 633
- HGS
- 634
- AATF.
1,274 more elements
Dependencies are inferred from the claim text.