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US 12,545,934 B2Granted
Methods for production of oxygenated terpenes
AssigneesGivaudan SA, Manus Bio Inc.
InventorsAjikumar Parayil Kumaran, Chin Giaw Lim, Liwei Li, Souvik Ghosh, Christopher Pirie, Anthony Qualley, Geoff Marshall-Hill, Martin Preininger
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Abstract
The present disclosure relates to methods for producing oxygenated terpenoids, and preparation of compositions and formulations thereof. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.
Claims10
A method of making a product for providing oxygenated terpenes, comprising:
- obtaining a formulation by contacting valencene with Stevia rebaudiana Kaurene Oxidase (SrKO) or an SrKO derivative comprising a sequence having at least 70% sequence identity to SEQ ID NO:
- 37, SEQ ID NO:
- 38, or SEQ ID NO:
- 55, and having valencene oxidizing activity in an in vitro or in vivo system to produce an oxygenated product comprising nootkatone, α-nootkatol, and β-nootkatol, and incorporating the formulation into a consumer product, an industrial product, a flavor product, a fragrance product, a cosmetic product, a cleaning product, a detergent product, a soap product, or a pest control product.
1 more element
Dependencies are inferred from the claim text.