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AssigneeAummune Ltd.
InventorsYaniv Amir, Almogit Abu-Horowitz, Ido Bachelet, Liron Anna Bassali, Elinor Debby, Liron Levy Efrati, Erez Lavi, Omer Levy, Noam Mamet Kedem, Anastasia Paz, Neria Reiss, Itai Rusinek, Ye'ela Scharff, Nir Skalka
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The present disclosure describes compositions and methods for selection functional aptamers. In certain embodiments, provided herein are methods of using aptamer cluster-containing particles to identify functional aptamers from an aptamer library. In certain embodiments, provided herein are functionally enriched populations of aptamers. In certain embodiments, provided herein are methods for selecting an aptamer for use in personalized cancer treatment and methods for preparing a tumor delivery system. In certain embodiments, provide herein are compositions comprise the aptamer cluster-containing particles, target cells (e.g., cancer cells, immune cells, etc.) and/or a detectable indicator of cellular function (e.g., a fluorescent indicator of apoptosis, cell proliferation, gene or protein expression, etc.).
A method for generating a functionally enriched population of aptamers, the method comprising:
Dependencies are inferred from the claim text.