CGAS/DNCV-like nucleotidyltransferases and uses thereof
AssigneesDana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
InventorsAaron Whiteley, Philip J. Kranzusch, John Mekalanos, James Eaglesham
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Abstract
The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides.
Claims12
A modified polypeptide that catalyzes production of cyclic di-purine nucleotides, wherein said polypeptide comprises an amino acid sequence having the cyclic dinucleotidyltransferase (CD-NTase) amino acid sequence of SEQ ID NO:
- 198 and further comprises amino acid residue S at the position corresponding to N166 of SEQ ID NO:
- 198.
Dependencies are inferred from the claim text.